CCG7_HUMAN
ID CCG7_HUMAN Reviewed; 275 AA.
AC P62955; Q52LL8; Q8VBX3; Q8WXS6; Q9BXT1;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Voltage-dependent calcium channel gamma-7 subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-7 subunit;
DE AltName: Full=Transmembrane AMPAR regulatory protein gamma-7;
DE Short=TARP gamma-7;
GN Name=CACNG7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11170751; DOI=10.1006/geno.2000.6440;
RA Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L.;
RT "A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome
RT 19q13.4: evolution and expression profile of the gamma subunit gene
RT family.";
RL Genomics 71:339-350(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA Chu P.-J., Robertson H.M., Best P.M.;
RT "Calcium channel gamma subunits provide insights into the evolution of this
RT gene family.";
RL Gene 280:37-48(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11927536; DOI=10.1093/emboj/21.7.1514;
RA Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C.,
RA Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.;
RT "The novel product of a five-exon stargazin-related gene abolishes CaV2.2
RT calcium channel expression.";
RL EMBO J. 21:1514-1523(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, AND SUBUNIT.
RX PubMed=21172611; DOI=10.1016/j.neuron.2010.11.026;
RA Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H.,
RA Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.;
RT "Hippocampal AMPA receptor gating controlled by both TARP and cornichon
RT proteins.";
RL Neuron 68:1082-1096(2010).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=21127204; DOI=10.1096/fj.10-172353;
RA Yang L., Katchman A., Morrow J.P., Doshi D., Marx S.O.;
RT "Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.";
RL FASEB J. 25:928-936(2011).
CC -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates
CC the trafficking and gating properties of AMPA-selective glutamate
CC receptors (AMPARs). Promotes their targeting to the cell membrane and
CC synapses and modulates their gating properties by slowing their rates
CC of activation, deactivation and desensitization and by mediating their
CC resensitization. Displays subunit-specific AMPA receptor regulation.
CC Shows specificity only for GRIA1 and GRIA2 (PubMed:21172611).
CC {ECO:0000269|PubMed:21127204, ECO:0000269|PubMed:21172611}.
CC -!- SUBUNIT: Interacts with CACNA1C. Identified in a complex with the L-
CC type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or
CC CACNB2 (PubMed:21127204). Acts as an auxiliary subunit for AMPA-
CC selective glutamate receptors (AMPARs), such as GRIA1 and GRIA2
CC (PubMed:21172611). {ECO:0000269|PubMed:21127204,
CC ECO:0000269|PubMed:21172611}.
CC -!- INTERACTION:
CC P62955; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-17499011, EBI-17498703;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:21127204};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in heart left ventricle (PubMed:21127204).
CC Widely expressed. {ECO:0000269|PubMed:11170751,
CC ECO:0000269|PubMed:21127204}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF288387; AAK20030.1; -; mRNA.
DR EMBL; AF361353; AAL50048.1; -; mRNA.
DR EMBL; AF458897; AAM00594.1; -; mRNA.
DR EMBL; BC069332; AAH69332.1; -; mRNA.
DR EMBL; BC093869; AAH93869.1; -; mRNA.
DR EMBL; BC113503; AAI13504.1; -; mRNA.
DR CCDS; CCDS12868.1; -.
DR RefSeq; NP_114102.2; NM_031896.4.
DR RefSeq; XP_016882582.1; XM_017027093.1.
DR AlphaFoldDB; P62955; -.
DR SMR; P62955; -.
DR BioGRID; 121870; 26.
DR IntAct; P62955; 2.
DR STRING; 9606.ENSP00000375647; -.
DR ChEMBL; CHEMBL2363032; -.
DR DrugBank; DB13746; Bioallethrin.
DR DrugBank; DB11148; Butamben.
DR DrugBank; DB00228; Enflurane.
DR DrugBank; DB00153; Ergocalciferol.
DR DrugBank; DB00421; Spironolactone.
DR TCDB; 8.A.16.2.5; the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.
DR iPTMnet; P62955; -.
DR PhosphoSitePlus; P62955; -.
DR BioMuta; CACNG7; -.
DR DMDM; 51702249; -.
DR MassIVE; P62955; -.
DR PaxDb; P62955; -.
DR PeptideAtlas; P62955; -.
DR PRIDE; P62955; -.
DR ProteomicsDB; 57459; -.
DR Antibodypedia; 32765; 110 antibodies from 23 providers.
DR DNASU; 59284; -.
DR Ensembl; ENST00000222212.6; ENSP00000222212.2; ENSG00000105605.8.
DR Ensembl; ENST00000391767.6; ENSP00000375647.1; ENSG00000105605.8.
DR GeneID; 59284; -.
DR KEGG; hsa:59284; -.
DR MANE-Select; ENST00000391767.6; ENSP00000375647.1; NM_031896.5; NP_114102.2.
DR UCSC; uc002qcr.3; human.
DR CTD; 59284; -.
DR DisGeNET; 59284; -.
DR GeneCards; CACNG7; -.
DR HGNC; HGNC:13626; CACNG7.
DR HPA; ENSG00000105605; Group enriched (brain, retina).
DR MIM; 606899; gene.
DR neXtProt; NX_P62955; -.
DR OpenTargets; ENSG00000105605; -.
DR PharmGKB; PA26021; -.
DR VEuPathDB; HostDB:ENSG00000105605; -.
DR eggNOG; ENOG502QTQ7; Eukaryota.
DR GeneTree; ENSGT01050000244961; -.
DR HOGENOM; CLU_053704_1_1_1; -.
DR InParanoid; P62955; -.
DR OMA; RPRMSNC; -.
DR OrthoDB; 1093662at2759; -.
DR PhylomeDB; P62955; -.
DR TreeFam; TF327980; -.
DR PathwayCommons; P62955; -.
DR Reactome; R-HSA-5576892; Phase 0 - rapid depolarisation.
DR Reactome; R-HSA-5576893; Phase 2 - plateau phase.
DR SignaLink; P62955; -.
DR BioGRID-ORCS; 59284; 18 hits in 1064 CRISPR screens.
DR ChiTaRS; CACNG7; human.
DR GenomeRNAi; 59284; -.
DR Pharos; P62955; Tdark.
DR PRO; PR:P62955; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P62955; protein.
DR Bgee; ENSG00000105605; Expressed in cortical plate and 81 other tissues.
DR ExpressionAtlas; P62955; baseline and differential.
DR Genevisible; P62955; HS.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; ISS:UniProtKB.
DR GO; GO:0044300; C:cerebellar mossy fiber; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:1990454; C:L-type voltage-gated calcium channel complex; IDA:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; NAS:UniProtKB.
DR GO; GO:0005246; F:calcium channel regulator activity; IDA:UniProtKB.
DR GO; GO:0016247; F:channel regulator activity; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0006816; P:calcium ion transport; NAS:UniProtKB.
DR GO; GO:0099590; P:neurotransmitter receptor internalization; IBA:GO_Central.
DR GO; GO:0099645; P:neurotransmitter receptor localization to postsynaptic specialization membrane; IEA:Ensembl.
DR GO; GO:0098943; P:neurotransmitter receptor transport, postsynaptic endosome to lysosome; IBA:GO_Central.
DR GO; GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IBA:GO_Central.
DR GO; GO:2000311; P:regulation of AMPA receptor activity; IDA:UniProtKB.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:Ensembl.
DR GO; GO:0019226; P:transmission of nerve impulse; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008371; VDCC_g7su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107:SF12; PTHR12107:SF12; 1.
DR Pfam; PF13903; Claudin_2; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01795; VDCCGAMMA7.
PE 1: Evidence at protein level;
KW Calcium; Calcium channel; Calcium transport; Cell membrane; Ion channel;
KW Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..275
FT /note="Voltage-dependent calcium channel gamma-7 subunit"
FT /id="PRO_0000164687"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 222
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62956"
FT MOD_RES 225
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62956"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62956"
FT CONFLICT 191..275
FT /note="GAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQFLQPEAWRRGRS
FT PSDISSDVSIQMTQNYPPAIKYPDHLHISTSPC -> VTSVGPRL (in Ref. 1;
FT AAK20030)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 275 AA; 31003 MW; 43CC82B9FA6A5C73 CRC64;
MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV KMALHAGLWR
VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA TPFPMVSLFL VFTAFVISNI
GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEV MNRPSSSEQY FHYRYGWSFA
FAASSFLLKE GAGVMSVYLF TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG
RSPSDISSDV SIQMTQNYPP AIKYPDHLHI STSPC
