CCG7_MOUSE
ID CCG7_MOUSE Reviewed; 275 AA.
AC P62956; Q8VBX3; Q8WXS6; Q9BXT1;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Voltage-dependent calcium channel gamma-7 subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-7 subunit;
DE AltName: Full=Transmembrane AMPAR regulatory protein gamma-7;
DE Short=TARP gamma-7;
GN Name=Cacng7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA Chu P.-J., Robertson H.M., Best P.M.;
RT "Calcium channel gamma subunits provide insights into the evolution of this
RT gene family.";
RL Gene 280:37-48(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=TKDU;
RX PubMed=11927536; DOI=10.1093/emboj/21.7.1514;
RA Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C.,
RA Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.;
RT "The novel product of a five-exon stargazin-related gene abolishes CaV2.2
RT calcium channel expression.";
RL EMBO J. 21:1514-1523(2002).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-222; SER-225 AND SER-273, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC contain CACNA1C as pore-forming subunit (By similarity). Regulates the
CC trafficking and gating properties of AMPA-selective glutamate receptors
CC (AMPARs). Promotes their targeting to the cell membrane and synapses
CC and modulates their gating properties by slowing their rates of
CC activation, deactivation and desensitization and by mediating their
CC resensitization (By similarity). Shows specificity only for GRIA1 and
CC GRIA2 (By similarity). {ECO:0000250|UniProtKB:P62955,
CC ECO:0000250|UniProtKB:P62957}.
CC -!- SUBUNIT: Interacts with CACNA1C. Identified in a complex with the L-
CC type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or
CC CACNB2 (By similarity). Acts as an auxiliary subunit for AMPA-selective
CC glutamate receptors (AMPARs), such as GRIA1 and GRIA2 (By similarity).
CC {ECO:0000250|UniProtKB:P62955, ECO:0000250|UniProtKB:P62957}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P62955};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000305}.
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DR EMBL; AF361349; AAL50044.1; -; mRNA.
DR EMBL; AF458899; AAM00596.1; -; mRNA.
DR CCDS; CCDS39725.1; -.
DR RefSeq; NP_573452.3; NM_133189.3.
DR RefSeq; XP_006540504.1; XM_006540441.3.
DR AlphaFoldDB; P62956; -.
DR SMR; P62956; -.
DR STRING; 10090.ENSMUSP00000090567; -.
DR iPTMnet; P62956; -.
DR PhosphoSitePlus; P62956; -.
DR SwissPalm; P62956; -.
DR PaxDb; P62956; -.
DR PRIDE; P62956; -.
DR ProteomicsDB; 281508; -.
DR Antibodypedia; 32765; 110 antibodies from 23 providers.
DR DNASU; 81904; -.
DR Ensembl; ENSMUST00000092891; ENSMUSP00000090567; ENSMUSG00000069806.
DR GeneID; 81904; -.
DR KEGG; mmu:81904; -.
DR UCSC; uc009euu.1; mouse.
DR CTD; 59284; -.
DR MGI; MGI:1932374; Cacng7.
DR VEuPathDB; HostDB:ENSMUSG00000069806; -.
DR eggNOG; ENOG502QTQ7; Eukaryota.
DR GeneTree; ENSGT01050000244961; -.
DR HOGENOM; CLU_053704_1_1_1; -.
DR InParanoid; P62956; -.
DR OMA; RPRMSNC; -.
DR OrthoDB; 1093662at2759; -.
DR PhylomeDB; P62956; -.
DR TreeFam; TF327980; -.
DR Reactome; R-MMU-5576892; Phase 0 - rapid depolarisation.
DR Reactome; R-MMU-5576893; Phase 2 - plateau phase.
DR BioGRID-ORCS; 81904; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Cacng7; mouse.
DR PRO; PR:P62956; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P62956; protein.
DR Bgee; ENSMUSG00000069806; Expressed in olfactory bulb and 71 other tissues.
DR ExpressionAtlas; P62956; baseline and differential.
DR Genevisible; P62956; MM.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; ISS:UniProtKB.
DR GO; GO:0044300; C:cerebellar mossy fiber; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005769; C:early endosome; ISO:MGI.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; ISO:MGI.
DR GO; GO:1990454; C:L-type voltage-gated calcium channel complex; ISS:UniProtKB.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.
DR GO; GO:0016247; F:channel regulator activity; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0099590; P:neurotransmitter receptor internalization; IBA:GO_Central.
DR GO; GO:0099645; P:neurotransmitter receptor localization to postsynaptic specialization membrane; IDA:SynGO.
DR GO; GO:0098943; P:neurotransmitter receptor transport, postsynaptic endosome to lysosome; IBA:GO_Central.
DR GO; GO:1903861; P:positive regulation of dendrite extension; ISO:MGI.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IBA:GO_Central.
DR GO; GO:2000311; P:regulation of AMPA receptor activity; ISS:UniProtKB.
DR GO; GO:0043488; P:regulation of mRNA stability; ISO:MGI.
DR GO; GO:0019226; P:transmission of nerve impulse; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008371; VDCC_g7su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107:SF12; PTHR12107:SF12; 1.
DR Pfam; PF13903; Claudin_2; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01795; VDCCGAMMA7.
PE 1: Evidence at protein level;
KW Calcium; Calcium channel; Calcium transport; Cell membrane; Ion channel;
KW Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..275
FT /note="Voltage-dependent calcium channel gamma-7 subunit"
FT /id="PRO_0000164688"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 222
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 225
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 275 AA; 31003 MW; 43CC82B9FA6A5C73 CRC64;
MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV KMALHAGLWR
VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA TPFPMVSLFL VFTAFVISNI
GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEV MNRPSSSEQY FHYRYGWSFA
FAASSFLLKE GAGVMSVYLF TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG
RSPSDISSDV SIQMTQNYPP AIKYPDHLHI STSPC
