ID   CCG8_NEUCR              Reviewed;         661 AA.
AC   Q01306; Q7RVB9; Q86ZI0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 3.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Clock-controlled protein 8;
GN   Name=ccg-8; ORFNames=64C2.120, NCU09686;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC   STRAIN=FRQ7 / 695-425 / FGSC 4898;
RX   PubMed=8917550; DOI=10.1073/pnas.93.23.13096;
RA   Bell-Pedersen D., Shinohara M.L., Loros J.J., Dunlap J.C.;
RT   "Circadian clock-controlled genes isolated from Neurospora crassa are late
RT   night- to early morning-specific.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:13096-13101(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 503-644.
RA   Shinohara M.L., Bell-Pedersen D., Loros J.J., Dunlap J.C.;
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- INDUCTION: Expression levels may be influenced by circadian rhythms.
CC       {ECO:0000269|PubMed:8917550}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC64286.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF088907; AAC64286.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BX294009; CAD70728.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA31382.2; -; Genomic_DNA.
DR   EMBL; U46087; AAA98471.1; -; mRNA.
DR   PIR; T47212; T47212.
DR   RefSeq; XP_960618.2; XM_955525.3.
DR   AlphaFoldDB; Q01306; -.
DR   SMR; Q01306; -.
DR   STRING; 5141.EFNCRP00000009386; -.
DR   PRIDE; Q01306; -.
DR   EnsemblFungi; EAA31382; EAA31382; NCU09686.
DR   GeneID; 3876765; -.
DR   KEGG; ncr:NCU09686; -.
DR   VEuPathDB; FungiDB:NCU09686; -.
DR   HOGENOM; CLU_015714_0_0_1; -.
DR   InParanoid; Q01306; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013927; TF_Opi1.
DR   PANTHER; PTHR38406; PTHR38406; 1.
DR   Pfam; PF08618; Opi1; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..661
FT                   /note="Clock-controlled protein 8"
FT                   /id="PRO_0000089414"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          354..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..206
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..238
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..369
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        614
FT                   /note="T -> P (in Ref. 1; AAC64286 and 4; AAA98471)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   661 AA;  73265 MW;  0BF8E8519C187E8D CRC64;
     MEHHHHHRHM HSPSSQQHEH QQHQQYQQPP QHHQHYEAPQ HQQQHQHHHH QQQQQQHPVP
     VPKQEQADNT SAPVLSALPA YPTLPPIWDS THSPALSASS SSTMQASASS LSSLPPLVLH
     PPSNGLQPNK PRSRSPSSNR FQTREPAPLS LFDGSPTTEL PPIQLDRKRS SSDHSLPSIA
     SLNVGSSLPT LQPTPTPQPP PKFVWPNSNP LSAYYAESDN DGRGASPQHR HDRRSTSVSL
     DDPQVMMAIS ALNELKTDSV SSPPNRNAPL RRGMTDQNQE PEPLLSLITT AHPIIESTVQ
     RSSHLYTKTK NFSPRIRSGL EYVEGSLIPV ADTVNNVGRR TGIESGVRWI LGKRTKSSSD
     TRESGQNKRH MTSRPVNGTG GEARFSEAPT ADASRRTSVS TIETLPAYDD QRSPAYSETV
     EQNGQAVDPK SALHAQLGNG RVQVTTSSLK ETMKEESLRS LKYVLETLRD VTNTLQQGTN
     ELSSVLDQYD RSTTTRDGED HVMTNGSAPE EDRTRLVERM TELRKSIYSN IKDVSSVVAN
     YTGAALPENA GNLVRHHLLS LPMVWSQASK TTTSSEQPNT QDPNALVRKA AKVALSFSKE
     GLHIFSQIME IIRTATDHAE DWRNKKMNQM TPANGTEQEI RPLIDQPLPQ VATINGDIPM
     R