CCGL_HUMAN
ID CCGL_HUMAN Reviewed; 190 AA.
AC Q8WXS4;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Voltage-dependent calcium channel gamma-like subunit {ECO:0000303|PubMed:11738816};
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-like subunit;
DE AltName: Full=Transmembrane protein 37;
GN Name=TMEM37 {ECO:0000312|HGNC:HGNC:18216};
GN Synonyms=PR {ECO:0000303|PubMed:11738816};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:AAL50051.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA Chu P.-J., Robertson H.M., Best P.M.;
RT "Calcium channel gamma subunits provide insights into the evolution of this
RT gene family.";
RL Gene 280:37-48(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- FUNCTION: Thought to stabilize the calcium channel in an inactivated
CC (closed) state. Modulates calcium current when coexpressed with CACNA1G
CC (By similarity). {ECO:0000250|UniProtKB:Q9JJV3}.
CC -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC alpha-1, alpha-2/delta, beta and gamma. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000255}.
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DR EMBL; AF361356; AAL50051.1; -; mRNA.
DR EMBL; AC013275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS33281.1; -.
DR RefSeq; NP_899063.2; NM_183240.2.
DR AlphaFoldDB; Q8WXS4; -.
DR BioGRID; 126681; 7.
DR IntAct; Q8WXS4; 6.
DR STRING; 9606.ENSP00000303148; -.
DR PhosphoSitePlus; Q8WXS4; -.
DR BioMuta; TMEM37; -.
DR DMDM; 296434430; -.
DR MassIVE; Q8WXS4; -.
DR PaxDb; Q8WXS4; -.
DR PeptideAtlas; Q8WXS4; -.
DR PRIDE; Q8WXS4; -.
DR ProteomicsDB; 75094; -.
DR Antibodypedia; 33375; 78 antibodies from 22 providers.
DR DNASU; 140738; -.
DR Ensembl; ENST00000306406.5; ENSP00000303148.4; ENSG00000171227.7.
DR GeneID; 140738; -.
DR KEGG; hsa:140738; -.
DR MANE-Select; ENST00000306406.5; ENSP00000303148.4; NM_183240.3; NP_899063.2.
DR UCSC; uc002tly.4; human.
DR CTD; 140738; -.
DR DisGeNET; 140738; -.
DR GeneCards; TMEM37; -.
DR HGNC; HGNC:18216; TMEM37.
DR HPA; ENSG00000171227; Tissue enhanced (kidney, liver, parathyroid gland).
DR MIM; 618831; gene.
DR neXtProt; NX_Q8WXS4; -.
DR OpenTargets; ENSG00000171227; -.
DR PharmGKB; PA134897608; -.
DR VEuPathDB; HostDB:ENSG00000171227; -.
DR eggNOG; ENOG502S0PU; Eukaryota.
DR GeneTree; ENSGT00390000006225; -.
DR HOGENOM; CLU_1383775_0_0_1; -.
DR InParanoid; Q8WXS4; -.
DR PhylomeDB; Q8WXS4; -.
DR TreeFam; TF333259; -.
DR PathwayCommons; Q8WXS4; -.
DR SignaLink; Q8WXS4; -.
DR BioGRID-ORCS; 140738; 12 hits in 1070 CRISPR screens.
DR ChiTaRS; TMEM37; human.
DR GenomeRNAi; 140738; -.
DR Pharos; Q8WXS4; Tbio.
DR PRO; PR:Q8WXS4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8WXS4; protein.
DR Bgee; ENSG00000171227; Expressed in kidney epithelium and 150 other tissues.
DR ExpressionAtlas; Q8WXS4; baseline and differential.
DR Genevisible; Q8WXS4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR029372; Tmem37.
DR PANTHER; PTHR31767; PTHR31767; 1.
DR Pfam; PF15108; TMEM37; 1.
PE 2: Evidence at transcript level;
KW Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT CHAIN 1..190
FT /note="Voltage-dependent calcium channel gamma-like
FT subunit"
FT /id="PRO_0000225601"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 7
FT /note="Q -> H (in Ref. 1; AAL50051)"
FT /evidence="ECO:0000305"
FT CONFLICT 70
FT /note="T -> SVP (in Ref. 1; AAL50051)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 190 AA; 20932 MW; CDDC58485DF57FD7 CRC64;
MTAVGVQAQR PLGQRQPRRS FFESFIRTLI ITCVALAVVL SSVSICDGHW LLAEDRLFGL
WHFCTTTNQT ICFRDLGQAH VPGLAVGMGL VRSVGALAVV AAIFGLEFLM VSQLCEDKHS
QCKWVMGSIL LLVSFVLSSG GLLGFVILLR NQVTLIGFTL MFWCEFTASF LLFLNAISGL
HINSITHPWE
