CCGL_MOUSE
ID CCGL_MOUSE Reviewed; 211 AA.
AC Q9JJV3; Q543K0;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Voltage-dependent calcium channel gamma-like subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-like subunit;
DE AltName: Full=Transmembrane protein 37;
GN Name=Tmem37; Synonyms=Cacng5, Pr, Pr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC TISSUE=Kidney;
RX PubMed=10734232; DOI=10.1016/s0014-5793(00)01306-5;
RA Klugbauer N., Dai S., Specht V., Lacinova L., Marais E., Bohn G.,
RA Hofmann F.;
RT "A family of gamma-like calcium channel subunits.";
RL FEBS Lett. 470:189-197(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, Kidney, and Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Thought to stabilize the calcium channel in an inactivated
CC (closed) state (By similarity). Modulates calcium current when
CC coexpressed with CACNA1G. {ECO:0000250, ECO:0000269|PubMed:10734232}.
CC -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC alpha-1, alpha-2/delta, beta and gamma. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000305}.
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DR EMBL; AJ272046; CAB86387.1; -; mRNA.
DR EMBL; AK002424; BAB22091.1; -; mRNA.
DR EMBL; AK050134; BAC34086.1; -; mRNA.
DR EMBL; AK086093; BAC39608.1; -; mRNA.
DR EMBL; BC024613; AAH24613.1; -; mRNA.
DR CCDS; CCDS15229.1; -.
DR RefSeq; NP_062305.1; NM_019432.2.
DR AlphaFoldDB; Q9JJV3; -.
DR STRING; 10090.ENSMUSP00000050862; -.
DR TCDB; 8.A.16.6.1; the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.
DR iPTMnet; Q9JJV3; -.
DR PhosphoSitePlus; Q9JJV3; -.
DR PaxDb; Q9JJV3; -.
DR PRIDE; Q9JJV3; -.
DR ProteomicsDB; 265722; -.
DR Antibodypedia; 33375; 78 antibodies from 22 providers.
DR Ensembl; ENSMUST00000056089; ENSMUSP00000050862; ENSMUSG00000050777.
DR GeneID; 170706; -.
DR KEGG; mmu:170706; -.
DR UCSC; uc007cjd.1; mouse.
DR CTD; 140738; -.
DR MGI; MGI:2157899; Tmem37.
DR VEuPathDB; HostDB:ENSMUSG00000050777; -.
DR eggNOG; ENOG502S0PU; Eukaryota.
DR GeneTree; ENSGT00390000006225; -.
DR HOGENOM; CLU_1383775_0_0_1; -.
DR InParanoid; Q9JJV3; -.
DR OMA; RRKWSMG; -.
DR OrthoDB; 1302934at2759; -.
DR PhylomeDB; Q9JJV3; -.
DR TreeFam; TF333259; -.
DR BioGRID-ORCS; 170706; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Cacng5; mouse.
DR PRO; PR:Q9JJV3; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9JJV3; protein.
DR Bgee; ENSMUSG00000050777; Expressed in placenta labyrinth and 127 other tissues.
DR Genevisible; Q9JJV3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR029372; Tmem37.
DR PANTHER; PTHR31767; PTHR31767; 1.
DR Pfam; PF15108; TMEM37; 1.
PE 2: Evidence at transcript level;
KW Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT CHAIN 1..211
FT /note="Voltage-dependent calcium channel gamma-like
FT subunit"
FT /id="PRO_0000164693"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 211 AA; 23230 MW; A1A05270E971CC03 CRC64;
MTAIGAQAHK LLGLKRPHRS FFESFIRTLI IVCTALAVVL SSVSICDGHW LLVEDHLFGL
WYFCTIGNHS EPHCLRDLSQ AHMPGLAVGM GLARSVAAMA VVAAIFGLEM LIVSQVCEDV
RSRRKWAIGS YLLLVAFILS SGGLLTFIIL LKNQINLLGF TLMFWCEFTA SFLFFLNAAS
GLHINSLTQP WDPPAGTLAY RKRGYDGTSL I
