CCGL_RAT
ID CCGL_RAT Reviewed; 209 AA.
AC Q8VHW1;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Voltage-dependent calcium channel gamma-like subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-like subunit;
DE AltName: Full=Transmembrane protein 37;
GN Name=Tmem37 {ECO:0000250|UniProtKB:Q9JJV3};
GN Synonyms=Pr1 {ECO:0000312|RGD:628689};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAL50050.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAL50050.1};
RX PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA Chu P.-J., Robertson H.M., Best P.M.;
RT "Calcium channel gamma subunits provide insights into the evolution of this
RT gene family.";
RL Gene 280:37-48(2001).
CC -!- FUNCTION: Thought to stabilize the calcium channel in an inactivated
CC (closed) state. Modulates calcium current when coexpressed with CACNA1G
CC (By similarity). {ECO:0000250|UniProtKB:Q9JJV3}.
CC -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC alpha-1, alpha-2/delta, beta and gamma. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000255}.
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DR EMBL; AF361355; AAL50050.1; -; mRNA.
DR RefSeq; NP_620795.1; NM_139095.1.
DR AlphaFoldDB; Q8VHW1; -.
DR STRING; 10116.ENSRNOP00000067466; -.
DR PaxDb; Q8VHW1; -.
DR PRIDE; Q8VHW1; -.
DR GeneID; 245953; -.
DR KEGG; rno:245953; -.
DR CTD; 140738; -.
DR RGD; 628689; Tmem37.
DR eggNOG; ENOG502S0PU; Eukaryota.
DR InParanoid; Q8VHW1; -.
DR OrthoDB; 1302934at2759; -.
DR PhylomeDB; Q8VHW1; -.
DR PRO; PR:Q8VHW1; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR029372; Tmem37.
DR PANTHER; PTHR31767; PTHR31767; 1.
DR Pfam; PF15108; TMEM37; 1.
PE 2: Evidence at transcript level;
KW Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT CHAIN 1..209
FT /note="Voltage-dependent calcium channel gamma-like
FT subunit"
FT /evidence="ECO:0000305"
FT /id="PRO_0000225602"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 209 AA; 22871 MW; 8DAE9B111BC45297 CRC64;
MTAIGAQAYK LLGPKRPHRS FFESFIRTLI IVCTALAVVL SSVSICDGHW LLVEDRLFGL
WYFCTISNHS EPHCLRDLSQ AQVPGVAVGM GLARSVAAMA VVAAIFGLEL LIVSQVCEDV
RSRSKWAIGS YLLLVAFILS SGGLLTFIIL LKNQITLMGF TLMFWCEFTA SFLFFLNATS
GLHINSLTRS PPAGTLAYRK QGYDGTSLI