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CCGL_RAT
ID   CCGL_RAT                Reviewed;         209 AA.
AC   Q8VHW1;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Voltage-dependent calcium channel gamma-like subunit;
DE   AltName: Full=Neuronal voltage-gated calcium channel gamma-like subunit;
DE   AltName: Full=Transmembrane protein 37;
GN   Name=Tmem37 {ECO:0000250|UniProtKB:Q9JJV3};
GN   Synonyms=Pr1 {ECO:0000312|RGD:628689};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAL50050.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAL50050.1};
RX   PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA   Chu P.-J., Robertson H.M., Best P.M.;
RT   "Calcium channel gamma subunits provide insights into the evolution of this
RT   gene family.";
RL   Gene 280:37-48(2001).
CC   -!- FUNCTION: Thought to stabilize the calcium channel in an inactivated
CC       (closed) state. Modulates calcium current when coexpressed with CACNA1G
CC       (By similarity). {ECO:0000250|UniProtKB:Q9JJV3}.
CC   -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC       alpha-1, alpha-2/delta, beta and gamma. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC       {ECO:0000255}.
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DR   EMBL; AF361355; AAL50050.1; -; mRNA.
DR   RefSeq; NP_620795.1; NM_139095.1.
DR   AlphaFoldDB; Q8VHW1; -.
DR   STRING; 10116.ENSRNOP00000067466; -.
DR   PaxDb; Q8VHW1; -.
DR   PRIDE; Q8VHW1; -.
DR   GeneID; 245953; -.
DR   KEGG; rno:245953; -.
DR   CTD; 140738; -.
DR   RGD; 628689; Tmem37.
DR   eggNOG; ENOG502S0PU; Eukaryota.
DR   InParanoid; Q8VHW1; -.
DR   OrthoDB; 1302934at2759; -.
DR   PhylomeDB; Q8VHW1; -.
DR   PRO; PR:Q8VHW1; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR029372; Tmem37.
DR   PANTHER; PTHR31767; PTHR31767; 1.
DR   Pfam; PF15108; TMEM37; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   CHAIN           1..209
FT                   /note="Voltage-dependent calcium channel gamma-like
FT                   subunit"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000225602"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   209 AA;  22871 MW;  8DAE9B111BC45297 CRC64;
     MTAIGAQAYK LLGPKRPHRS FFESFIRTLI IVCTALAVVL SSVSICDGHW LLVEDRLFGL
     WYFCTISNHS EPHCLRDLSQ AQVPGVAVGM GLARSVAAMA VVAAIFGLEL LIVSQVCEDV
     RSRSKWAIGS YLLLVAFILS SGGLLTFIIL LKNQITLMGF TLMFWCEFTA SFLFFLNATS
     GLHINSLTRS PPAGTLAYRK QGYDGTSLI
 
 
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