ID   CCHA2_AGRIP             Reviewed;         140 AA.
AC   C0HKT1;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2018, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Neuropeptide CCHamide-2 {ECO:0000303|PubMed:29466015};
DE            Short=CCHa {ECO:0000303|PubMed:29466015};
DE   Flags: Precursor;
OS   Agrotis ipsilon (Black cutworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Noctuinae; Noctuini; Agrotis.
OX   NCBI_TaxID=56364;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-37, TISSUE SPECIFICITY,
RP   MASS SPECTROMETRY, IDENTIFICATION BY MASS SPECTROMETRY, AND AMIDATION AT
RP   HIS-37.
RX   PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA   Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA   Schachtner J., Jacquin-Joly E., Gadenne C.;
RT   "Mating-induced differential peptidomics of neuropeptides and protein
RT   hormones in Agrotis ipsilon moths.";
RL   J. Proteome Res. 17:1397-1414(2018).
CC   -!- FUNCTION: Ligand for the CCHamide-2 receptor CCHa2-R.
CC       {ECO:0000250|UniProtKB:Q8SXL2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in corpora cardiaca (CC), corpora allata
CC       (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level).
CC       Expression detected in few animals (at protein level).
CC       {ECO:0000269|PubMed:29466015}.
CC   -!- MASS SPECTROMETRY: Mass=1263.49; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:29466015};
CC   -!- CAUTION: Further mature peptides might exist. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKT1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         25..37
FT                   /note="Neuropeptide CCHamide-2"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444222"
FT   PROPEP          41..140
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444223"
FT   MOD_RES         37
FT                   /note="Histidine amide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT   DISULFID        26..33
FT                   /evidence="ECO:0000250|UniProtKB:Q8SXL2"
SQ   SEQUENCE   140 AA;  15454 MW;  C53C0185E254B940 CRC64;
     MAQMYLAVTI IALLAISHGV SAKRGCSAFG HSCFGGHGKR SGDTSAMDQL SNQDGVLMAR
     HQLGQEETPP HPVYPHSGYN VLASGDDIIP IRDGGVYDRE DGGAAREVMK MKLRNIFKHW
     MDNYRRSQQN PDDGYYIESL