ID   CCHCR_GORGO             Reviewed;         782 AA.
AC   Q8HZ59;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Coiled-coil alpha-helical rod protein 1;
DE   AltName: Full=Alpha-helical coiled-coil rod protein;
GN   Name=CCHCR1; Synonyms=HCR;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Asumalahti K., Kere J.;
RT   "HCR gene orthologs in chimpanzee, pygmy chimpanzee, gorilla, and
RT   orangutan.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a regulator of keratinocyte proliferation or
CC       differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY135795; AAN12280.1; -; Genomic_DNA.
DR   EMBL; AY135779; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135780; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135781; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135782; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135783; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135784; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135785; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135786; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135787; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135788; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135789; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135790; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135791; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135792; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135793; AAN12280.1; JOINED; Genomic_DNA.
DR   EMBL; AY135794; AAN12280.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q8HZ59; -.
DR   SMR; Q8HZ59; -.
DR   STRING; 9593.ENSGGOP00000010913; -.
DR   eggNOG; KOG3802; Eukaryota.
DR   InParanoid; Q8HZ59; -.
DR   Proteomes; UP000001519; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR   InterPro; IPR009800; HCR.
DR   PANTHER; PTHR46822; PTHR46822; 1.
DR   Pfam; PF07111; HCR; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Developmental protein; Differentiation; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..782
FT                   /note="Coiled-coil alpha-helical rod protein 1"
FT                   /id="PRO_0000089415"
FT   REGION          62..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          82..314
FT                   /evidence="ECO:0000255"
FT   COILED          344..398
FT                   /evidence="ECO:0000255"
FT   COILED          498..691
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        62..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..218
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   782 AA;  88428 MW;  63424E181E7077F3 CRC64;
     MFPPSGSTGL IPPSHFQARP LSTLPRMAPT WLSDIPLVQP PGHQDVSERQ LDTQRPQVTM
     WERDVSSDRQ EPGRRGRSWG LEGSQALSQQ AEVIARQLQE LRRLEEEVRL LRETSLQQKM
     RLEAQAMELE ALARAEKAGR AEAEGLRAAL AGAEVVRKNL EEGSQRELEE VQRLHQEQLS
     SLTQAHKEAL SSLTSKAEGL EKSLSSLETR RAGEAKELAE AQREAELLRK QLSKTQEDLE
     AQVTLVENLR KYVGEQVPSE VHSQTWELER QKLLETMQHL QEDRDSLQAT AELLQVRVQS
     LTHILALQEE ELTRKVQPSD SLEPEFTRKC QSLLNRWREK VFALMVQLKA QELEHSDSVK
     QLKGQVASLQ EKVTSQSQEQ AILQQSLQDK AAEVEVERMG AKGLQLELSR AQEARCRWQQ
     QTASAEEQLR LVVNAVSSSQ IWLETTMAKV EGAAAQLPSL NNRLSYAVRK VHTIRGLIAQ
     KLALAQLRQE SCPLPPPVTD VSLELQQLRE ERNRLDAELQ LSARLIQQEV GRAREQGEAE
     RQQLSKVAQQ LEQELQQTQE SLASLGLQLE VARQGQQEST EEAASLRQEL TQQQELYGQA
     LQEKVAEVET RLREQLSDTE RRLNEARREH AKAVVSLRQI QRRAAQEKER SQELRRLQEE
     ARKEEGQRLA RRLQELERDK NLMLATLQQE GLLSRYKQQR LLTVLPSLLD KKKSVVSSPR
     PPECSASASV AAAVPTRESI KGSLSVLLDD LQGLSEAISK EEAVCQGDNL DRCSSSNPQM
     SS