CCHCR_MOUSE
ID CCHCR_MOUSE Reviewed; 770 AA.
AC Q8K2I2; G3UWG0;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Coiled-coil alpha-helical rod protein 1;
DE AltName: Full=Alpha-helical coiled-coil rod protein;
GN Name=Cchcr1; Synonyms=Hcr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a regulator of keratinocyte proliferation or
CC differentiation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH31416.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CR974473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466559; EDL23219.1; -; Genomic_DNA.
DR EMBL; BC031416; AAH31416.1; ALT_INIT; mRNA.
DR CCDS; CCDS50090.1; -.
DR RefSeq; NP_666360.2; NM_146248.2.
DR AlphaFoldDB; Q8K2I2; -.
DR SMR; Q8K2I2; -.
DR BioGRID; 232162; 1.
DR STRING; 10090.ENSMUSP00000046612; -.
DR iPTMnet; Q8K2I2; -.
DR PhosphoSitePlus; Q8K2I2; -.
DR MaxQB; Q8K2I2; -.
DR PaxDb; Q8K2I2; -.
DR PRIDE; Q8K2I2; -.
DR ProteomicsDB; 265610; -.
DR Antibodypedia; 53233; 98 antibodies from 21 providers.
DR Ensembl; ENSMUST00000045956; ENSMUSP00000046612; ENSMUSG00000040312.
DR Ensembl; ENSMUST00000164242; ENSMUSP00000132028; ENSMUSG00000040312.
DR GeneID; 240084; -.
DR KEGG; mmu:240084; -.
DR UCSC; uc008chy.2; mouse.
DR CTD; 54535; -.
DR MGI; MGI:2385321; Cchcr1.
DR VEuPathDB; HostDB:ENSMUSG00000040312; -.
DR eggNOG; KOG3802; Eukaryota.
DR GeneTree; ENSGT00940000153251; -.
DR HOGENOM; CLU_009996_0_0_1; -.
DR InParanoid; Q8K2I2; -.
DR OrthoDB; 1046571at2759; -.
DR TreeFam; TF336947; -.
DR BioGRID-ORCS; 240084; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Cchcr1; mouse.
DR PRO; PR:Q8K2I2; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8K2I2; protein.
DR Bgee; ENSMUSG00000040312; Expressed in spermatocyte and 122 other tissues.
DR ExpressionAtlas; Q8K2I2; baseline and differential.
DR Genevisible; Q8K2I2; MM.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006611; P:protein export from nucleus; IDA:MGI.
DR InterPro; IPR009800; HCR.
DR PANTHER; PTHR46822; PTHR46822; 1.
DR Pfam; PF07111; HCR; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Developmental protein; Differentiation; Nucleus;
KW Reference proteome.
FT CHAIN 1..770
FT /note="Coiled-coil alpha-helical rod protein 1"
FT /id="PRO_0000089417"
FT REGION 573..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 56..289
FT /evidence="ECO:0000255"
FT COILED 334..420
FT /evidence="ECO:0000255"
FT COILED 476..669
FT /evidence="ECO:0000255"
FT COMPBIAS 646..672
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 720
FT /note="S -> L (in Ref. 3; AAH31416)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 770 AA; 87105 MW; CAC0D3143E0660C7 CRC64;
MLPPSGFAGL VPPSHFQARP LPTLPRMAPT WASDVPLVQS PASQDVLERR LDAQRSTVTT
WGQDFCGDGQ GLGRRGRSLE LGFSSALSQQ AELISRQLQE LRRLEEEVRS LRETSLQQKM
RLETQAVELD ALAVAEKAGQ AEAEGLRTAL AGAEMVRKNL EEAKHKELEE IQSLHQEQLS
SLTQAHQKAL DSLASKAEGL EKSLNSLETK RAGEAKQLAM AQKEADMLRN QLSKTQEELE
AQVTLVESLR KYVGEQVLPE FPSQEWELER KELLDTLKHL KEDRADLQAT VELLQVRVQS
LTHMLALQEE ELTRKIQPLD PLEPEFPKKC RSLLRNWREK VFALMVQLKA QDLQHRDSTS
QLRIQVAELQ EQVTSQSQEQ AILQRALQDK TAQVEVERMS TKSLQMELDQ AQEARRRQEQ
QIASAEEQLK FVVGAMNSTQ AKLQSTMTRM DQAVARIPSL SNRLSYAVRK VHTIKGLMAR
KVALAQLRVE SSPPSEAAPP LDTDLSVELE QLREERNRLD AELQLSAHLI QQEVGRAREQ
GEVERRRLIE VAQQLEQELQ RAQESLASVG QQLEAARRGQ QESTEEAASL RQELTQQQEI
YGQALQEKVA EVETRLREQL SDTKRRLNEA RREQAKAVVS LRQIQHKATQ EKERNQELRR
LQDEARKEEG QRLTRRVQEL ERDKNLMLQR LLAVLPSGVN KKCSPRSVES SSSESPAAAS
CKESVKGSLT VLLDNLQGLS EAISRDEDIC VEDNQNTKKT KNPPSDPLLS
