ID   CCHCR_PANPA             Reviewed;         782 AA.
AC   Q8HZ57;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Coiled-coil alpha-helical rod protein 1;
DE   AltName: Full=Alpha-helical coiled-coil rod protein;
GN   Name=CCHCR1; Synonyms=HCR;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Asumalahti K., Kere J.;
RT   "HCR gene orthologs in chimpanzee, pygmy chimpanzee, gorilla, and
RT   orangutan.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a regulator of keratinocyte proliferation or
CC       differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; AY135831; AAN12282.1; -; Genomic_DNA.
DR   EMBL; AY135815; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135816; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135817; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135818; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135819; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135820; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135821; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135822; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135823; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135824; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135825; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135826; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135827; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135828; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135829; AAN12282.1; JOINED; Genomic_DNA.
DR   EMBL; AY135830; AAN12282.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q8HZ57; -.
DR   SMR; Q8HZ57; -.
DR   STRING; 9597.XP_008957683.1; -.
DR   eggNOG; KOG3802; Eukaryota.
DR   Proteomes; UP000240080; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   InterPro; IPR009800; HCR.
DR   PANTHER; PTHR46822; PTHR46822; 1.
DR   Pfam; PF07111; HCR; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Developmental protein; Differentiation; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..782
FT                   /note="Coiled-coil alpha-helical rod protein 1"
FT                   /id="PRO_0000089418"
FT   REGION          62..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          82..314
FT                   /evidence="ECO:0000255"
FT   COILED          344..437
FT                   /evidence="ECO:0000255"
FT   COILED          498..691
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        62..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..218
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   782 AA;  88688 MW;  6F07A52DA6741377 CRC64;
     MFPPSGSTGL IPPSHFQARP LSTLPRMAPT WLSDIPLVQP PGHQDVSERR LDTQRPQVTM
     WERDVSSDRQ EPGRRGRSWG LEGSQALSQQ AEVIARQLQE LRRLEEEVRL LRETSLQQKM
     RLEAQAMELE ALARAEKAGR AEAEGLRAAL AGAEVVRKNL EEGSQRELEE VQRLHQEQLS
     SLTQAHEEAL SSLTSKAEGL EKSLSSLETR RAGEAKELAE AQREAELLRK QLSKTQEDLE
     AQVTLVENLR KYVGEQVPSE VHSQTWELER QKLLETMQHL QEDRDSLQAT VELLQVRVQS
     LTHILALQEE ELTRKVQPSD SLEPEFTRKC QSLLNRWREK VFALMVQLKA QELEHSDSVK
     QLKGQVASLQ EKVTSQSQEQ AILQRSLQDK AAEVEVERMG AKGLQLELSR AQEARRRWQQ
     QTASAEEQLR LVVNAVSSSQ IWLETTMAKV EEAAAQLPSL NNRLSYAVRK VHTIRGLIAR
     KLALAQLRQE SCPLPPPVAD VSLELQQLRE ERNRLDAELQ LSARLIQQEV GRAREQGEAE
     RQQLSKVAQQ LERELQQTQE SLASLGLQLE VARQGQQEST EEAASLRQEL TQQQELYGQA
     LQEKVAEVET RLREQLSDTE RRLNEARREH AKAVVSLRQI QRRAAQEKER SQELRRLQEE
     ARKEEGQRLA RRLQELERDK NLMLATLQQE GLLSRYKQQR LLTVLPSLLD KKKSVVSSPR
     PPECSASAPI AAAVPTRESI KGSLSVLLDD LQGLSEAISK EEAVCQGDNL DRCSSSNPQM
     SS