CCHCR_PANTR
ID CCHCR_PANTR Reviewed; 782 AA.
AC Q8HZ60; Q7YR47;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Coiled-coil alpha-helical rod protein 1;
DE AltName: Full=Alpha-helical coiled-coil rod protein;
GN Name=CCHCR1; Synonyms=HCR;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Asumalahti K., Kere J.;
RT "HCR gene orthologs in chimpanzee, pygmy chimpanzee, gorilla, and
RT orangutan.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12799463; DOI=10.1073/pnas.1230533100;
RA Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A.,
RA Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y.,
RA Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., Meyer A.,
RA Ikeo K., Gojobori T., Bahram S., Inoko H.;
RT "Comparative sequencing of human and chimpanzee MHC class I regions unveils
RT insertions/deletions as the major path to genomic divergence.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003).
CC -!- FUNCTION: May be a regulator of keratinocyte proliferation or
CC differentiation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC78167.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY135777; AAN12279.1; -; Genomic_DNA.
DR EMBL; AY135761; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135762; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135763; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135764; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135765; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135766; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135767; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135768; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135769; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135770; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135771; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135772; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135773; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135774; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135775; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; AY135776; AAN12279.1; JOINED; Genomic_DNA.
DR EMBL; BA000041; BAC78167.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q8HZ60; -.
DR SMR; Q8HZ60; -.
DR InParanoid; Q8HZ60; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR InterPro; IPR009800; HCR.
DR PANTHER; PTHR46822; PTHR46822; 1.
DR Pfam; PF07111; HCR; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Developmental protein; Differentiation; Nucleus;
KW Reference proteome.
FT CHAIN 1..782
FT /note="Coiled-coil alpha-helical rod protein 1"
FT /id="PRO_0000089419"
FT REGION 62..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 82..314
FT /evidence="ECO:0000255"
FT COILED 344..437
FT /evidence="ECO:0000255"
FT COILED 498..691
FT /evidence="ECO:0000255"
FT COMPBIAS 62..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 288
FT /note="Q -> H (in Ref. 2; BAC78167)"
FT /evidence="ECO:0000305"
FT CONFLICT 319
FT /note="S -> T (in Ref. 2; BAC78167)"
FT /evidence="ECO:0000305"
FT CONFLICT 638
FT /note="R -> H (in Ref. 2; BAC78167)"
FT /evidence="ECO:0000305"
FT CONFLICT 671
FT /note="R -> Q (in Ref. 2; BAC78167)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 782 AA; 88660 MW; D140F8587129D054 CRC64;
MFPPSGSTGL IPPSHFQARP LSTLPRMAPT WLSDIPLVQP PGHQDVSERR LDTQRPQVTM
WERDVSSDRQ EPGRRGRSWG LEGSQALSQQ AEVIARQLQE LRRLEEEVRL LRETSLQQKM
RLEAQAMELE ALARAEKAGR AEAEGLRAAL AGAEVVRKNL EEGSQRELEE VQRLHQEQLS
SLTQAHEEAL SSLTSKAEGL EKSLSSLETR RAGEAKELAE AQREAELLRK QLSKTQEDLE
AQVTLVENLR KYVGEQVPSE VHSQTWELER QKLLETMQHL QEDRDSLQAT VELLQVRVQS
LTHILALQEE ELTRKVQPSD SLEPEFTRKC QSLLNRWREK VFALMVQLKA QELEHSDSVK
QLKGQVASLQ EKVTSQSQEQ AILQRSLQDK AAEVEVERMG AKGLQLELSR AQEARRRWQQ
QTASAEEQLR LVVNAVSSSQ IWLETTMAKV EEAAAQLPSL NNRLSYAVRK VHTIRGLIAR
KLALAQLRQE SCPLPPPVAD VSLELQQLRE ERNRLDAELQ LSARLIQQEV GRAREQGEAE
RQQLSKVAQQ LEQELQQTQE SLASLGLQLE VARQGQQEST EEAASLRQEL TQQQELYGQA
LQEKVAEVET RLREQLSDTE RRLNEARREH AKAVVSLRQI QRRAAQEKER SQELRRLQEE
ARKEEGQRLA RRLQELERDK NLMLATLQQE GLLSRYKQQR LLTVLPSLLD KKKSVVSSPR
PPECSASAPI AAAVPTRESI KGSLSVLLDD LQGLSEAISK EEAVCQGDNL DRCSSSNPQM
SS
