ID   CCHCR_PONPY             Reviewed;         782 AA.
AC   Q8HZ58;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Coiled-coil alpha-helical rod protein 1;
DE   AltName: Full=Alpha-helical coiled-coil rod protein;
GN   Name=CCHCR1; Synonyms=HCR;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Asumalahti K., Kere J.;
RT   "HCR gene orthologs in chimpanzee, pygmy chimpanzee, gorilla, and
RT   orangutan.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a regulator of keratinocyte proliferation or
CC       differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; AY135813; AAN12281.1; -; Genomic_DNA.
DR   EMBL; AY135797; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135798; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135799; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135800; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135801; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135802; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135803; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135804; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135805; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135806; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135807; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135808; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135809; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135810; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135811; AAN12281.1; JOINED; Genomic_DNA.
DR   EMBL; AY135812; AAN12281.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q8HZ58; -.
DR   SMR; Q8HZ58; -.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   InterPro; IPR009800; HCR.
DR   PANTHER; PTHR46822; PTHR46822; 1.
DR   Pfam; PF07111; HCR; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Developmental protein; Differentiation; Nucleus.
FT   CHAIN           1..782
FT                   /note="Coiled-coil alpha-helical rod protein 1"
FT                   /id="PRO_0000089421"
FT   REGION          62..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          82..314
FT                   /evidence="ECO:0000255"
FT   COILED          344..435
FT                   /evidence="ECO:0000255"
FT   COILED          498..691
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        62..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..218
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   782 AA;  88699 MW;  3B2FCCC61E648307 CRC64;
     MFPPSGSTGL IPPSHFQARP LSTLPRMAPT WLSDIPLVQP PGHQDVSERR LDTQRPQVTM
     WERDVSSDRQ EPGRRGRSWG LEGSQALSQQ AEVIARQLQE LRRLEEEVRL LRETSLQQKM
     RLEAQAMELE ALARAEKAGR TEAEGLRAAL AGAEVIRKNL EEGSQRELEE VQRLHQEQLS
     SLTQAHEEAL SSLTSKAEGL EKSLSSLETR RAGEAKELAE AQREAELLRK QLSKTQEDLE
     AQVTLVENLR KYVGEQVPSE VHSQTWELER QKLLETMQHL QEDRDSLQAT VELLQVRVQS
     LTHILALQEE ELTRKVQPSD SLEPEFTRKC QFLLNRWREK VFALMVQLKA QELEHSDSVK
     QLKGQVASLQ EQVTSQSQEQ AILQRSLQDK AAEVEVERIG AKGLQLELSR AQEARHRWQQ
     QTASAEEQLR LVVNAVSSSQ IWLETTMAKV EEAAAQLPSL NNRLSYAVRK VHTIRGLIAR
     KLALAQLRQE SCPLPPPVAD VSLELQQLRE ERNRLDAELQ LSARLIQQEV GRAREQGEAE
     RQQLSKVAQQ LEQELQQTQE SLASLGLQLE VARQGQQEST EEAASLRQEL TQQQELYGQA
     LQEKVAEVET QLREQLSDTE RRLNEARREH AKAVVSLRQI QRRAAQEKER SQELRRLQEE
     ARKEEGQRLA RRLQELERDK NLMLATLQQE GLLSRYKQQR LLTVLPSLLD KKKSVVSSPR
     PPECSASAPI AAAVPTRESI KGSLSVLLDD LQGLSEAISK EEAVCQGDNL DRCSSSNPQM
     SS