ID   CCHL_CAEEL              Reviewed;         280 AA.
AC   P53703;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Probable holocytochrome-c-type synthase {ECO:0000250|UniProtKB:P53701};
DE            EC=4.4.1.17 {ECO:0000250|UniProtKB:P53701};
DE   AltName: Full=Cytochrome c-type heme lyase {ECO:0000250|UniProtKB:P53701};
DE            Short=CCHL {ECO:0000250|UniProtKB:P53701};
GN   Name=cchl-1; ORFNames=T06D8.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probable lyase that catalyzes the covalent linking of the
CC       heme group to the cytochrome C apoprotein to produce the mature
CC       functional cytochrome. {ECO:0000250|UniProtKB:P53701}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=holo-[cytochrome c] = apo-[cytochrome c] + heme b;
CC         Xref=Rhea:RHEA:22648, Rhea:RHEA-COMP:10725, Rhea:RHEA-COMP:10726,
CC         ChEBI:CHEBI:29950, ChEBI:CHEBI:60344, ChEBI:CHEBI:83739; EC=4.4.1.17;
CC         Evidence={ECO:0000250|UniProtKB:P53701};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22650;
CC         Evidence={ECO:0000250|UniProtKB:P53701};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P53701}.
CC   -!- SIMILARITY: Belongs to the cytochrome c-type heme lyase family.
CC       {ECO:0000305}.
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DR   EMBL; Z49130; CAA88969.1; -; Genomic_DNA.
DR   PIR; T24579; T24579.
DR   RefSeq; NP_496403.1; NM_064002.5.
DR   AlphaFoldDB; P53703; -.
DR   BioGRID; 40022; 4.
DR   STRING; 6239.T06D8.6.1; -.
DR   EPD; P53703; -.
DR   PaxDb; P53703; -.
DR   PeptideAtlas; P53703; -.
DR   EnsemblMetazoa; T06D8.6.1; T06D8.6.1; WBGene00011527.
DR   GeneID; 174713; -.
DR   KEGG; cel:CELE_T06D8.6; -.
DR   UCSC; T06D8.6.1; c. elegans.
DR   CTD; 174713; -.
DR   WormBase; T06D8.6; CE02327; WBGene00011527; cchl-1.
DR   eggNOG; KOG3996; Eukaryota.
DR   GeneTree; ENSGT00390000004175; -.
DR   HOGENOM; CLU_048602_2_0_1; -.
DR   InParanoid; P53703; -.
DR   OMA; EGAWDEI; -.
DR   OrthoDB; 1282808at2759; -.
DR   PhylomeDB; P53703; -.
DR   PRO; PR:P53703; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00011527; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; HDA:WormBase.
DR   GO; GO:0004408; F:holocytochrome-c synthase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0018063; P:cytochrome c-heme linkage; IBA:GO_Central.
DR   InterPro; IPR000511; Holocyt_c/c1_synthase.
DR   PANTHER; PTHR12743; PTHR12743; 1.
DR   Pfam; PF01265; Cyto_heme_lyase; 1.
DR   PROSITE; PS00821; CYTO_HEME_LYASE_1; 1.
DR   PROSITE; PS00822; CYTO_HEME_LYASE_2; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Lyase; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat.
FT   CHAIN           1..280
FT                   /note="Probable holocytochrome-c-type synthase"
FT                   /id="PRO_0000121714"
FT   REPEAT          35..40
FT                   /note="HRM 1"
FT   REPEAT          56..61
FT                   /note="HRM 2"
FT   REGION          1..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  31263 MW;  8916E0315AA46724 CRC64;
     MGSSQSTPKV QDANADAERI RKAQHSMAAA GGGSQCPLTP EQRAAASGEN CGAGGACPVG
     ADKASINPLN NELEHPNQKP APDQPFALPT KREKSTIPKA GTETETWTYP SPQMFWNAML
     KKGWRWQDDS LSKSDMENII SIHNANNEEA WREVLKWENL LHPECAEPKL KSFKGDAKNL
     SPRARFRNLF LGYDLPFDRH DWIVDRCGTK QVQYVIDYYD GGAVDPSSKL FTILDVRPAV
     NDIGNIWDRM VVAYWRFKFE TLGFTPSLPI PPTEGHNVNH