CCHL_DICDI
ID CCHL_DICDI Reviewed; 211 AA.
AC Q552W5; Q86IF0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Probable holocytochrome-c-type synthase {ECO:0000250|UniProtKB:P53701};
DE EC=4.4.1.17 {ECO:0000250|UniProtKB:P53701};
DE AltName: Full=Cytochrome c-type heme lyase {ECO:0000250|UniProtKB:P53701};
DE Short=CCHL {ECO:0000250|UniProtKB:P53701};
GN Name=cchl; ORFNames=DDB_G0275895;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable lyase that catalyzes the covalent linking of the
CC heme group to the cytochrome C apoprotein to produce the mature
CC functional cytochrome. {ECO:0000250|UniProtKB:P53701}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[cytochrome c] = apo-[cytochrome c] + heme b;
CC Xref=Rhea:RHEA:22648, Rhea:RHEA-COMP:10725, Rhea:RHEA-COMP:10726,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:60344, ChEBI:CHEBI:83739; EC=4.4.1.17;
CC Evidence={ECO:0000250|UniProtKB:P53701};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22650;
CC Evidence={ECO:0000250|UniProtKB:P53701};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P53701}.
CC -!- SIMILARITY: Belongs to the cytochrome c-type heme lyase family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000013; EAL69698.1; -; Genomic_DNA.
DR RefSeq; XP_643563.1; XM_638471.1.
DR AlphaFoldDB; Q552W5; -.
DR STRING; 44689.DDB0266707; -.
DR PaxDb; Q552W5; -.
DR EnsemblProtists; EAL69698; EAL69698; DDB_G0275895.
DR GeneID; 8620147; -.
DR KEGG; ddi:DDB_G0275895; -.
DR dictyBase; DDB_G0275895; cchl.
DR eggNOG; KOG3996; Eukaryota.
DR HOGENOM; CLU_048602_3_0_1; -.
DR InParanoid; Q552W5; -.
DR OMA; DRCGNTI; -.
DR PhylomeDB; Q552W5; -.
DR PRO; PR:Q552W5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:dictyBase.
DR GO; GO:0004408; F:holocytochrome-c synthase activity; ISS:dictyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0018063; P:cytochrome c-heme linkage; ISS:dictyBase.
DR InterPro; IPR000511; Holocyt_c/c1_synthase.
DR PANTHER; PTHR12743; PTHR12743; 1.
DR Pfam; PF01265; Cyto_heme_lyase; 1.
DR PROSITE; PS00822; CYTO_HEME_LYASE_2; 1.
PE 3: Inferred from homology;
KW Heme; Iron; Lyase; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome.
FT CHAIN 1..211
FT /note="Probable holocytochrome-c-type synthase"
FT /id="PRO_0000332707"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 211 AA; 24440 MW; 14DCB885F0EC0A46 CRC64;
MGDDNTNNTS ITKSSPTDAM GGGCPIAHDI NPANHMYKPN QNPHPDQTKP LSTERITSTI
PRTEKDNWQY PSPQMFFNAM KKKQYEPKEE DMSVVISIHN TVNEKCWEDV LQWENDYKDV
CPNPKLKKFK GKATDFSPKA KFLNTFLGYK LPFDRHDWIV DRNGKEVRYV IDFYEGRINK
DSGKSIGIYI DVRPAIDDFS SLKDRVLHFF K
