ID   CCKN_MACGI              Reviewed;           8 AA.
AC   P0C229;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=Cholecystokinin;
DE            Short=CCK;
GN   Name=CCK;
OS   Macropus giganteus (Eastern gray kangaroo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Macropus.
OX   NCBI_TaxID=9317;
RN   [1]
RP   PROTEIN SEQUENCE, SULFATION AT TYR-2, AND AMIDATION AT PHE-8.
RC   TISSUE=Brain;
RX   PubMed=8134294; DOI=10.1016/0196-9781(93)90166-e;
RA   Johnsen A.H., Shulkes A.;
RT   "Gastrin and cholecystokinin in the Eastern Grey kangaroo, Macropus
RT   giganteus giganteus.";
RL   Peptides 14:1133-1139(1993).
CC   -!- FUNCTION: This peptide hormone induces gall bladder contraction and the
CC       release of pancreatic enzymes in the gut. Its function in the brain is
CC       not clear. Binding to CCK-A receptors stimulates amylase release from
CC       the pancreas, binding to CCK-B receptors stimulates gastric acid
CC       secretion. {ECO:0000250|UniProtKB:Q9TS44}.
CC   -!- SUBUNIT: Binds to CCK-A receptors in the pancreas and CCK-B receptors
CC       in the brain. {ECO:0000250|UniProtKB:Q9TS44}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:8134294}.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted; Sulfation.
FT   PEPTIDE         1..8
FT                   /note="Cholecystokinin"
FT                   /id="PRO_0000260279"
FT   MOD_RES         2
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000269|PubMed:8134294"
FT   MOD_RES         8
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:8134294"
SQ   SEQUENCE   8 AA;  1064 MW;  DDCAA68378768B5A CRC64;
     DYMGWMDF