ID   CCK_PYTMO               Reviewed;         125 AA.
AC   Q8JHB9;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Cholecystokinin-8;
DE            Short=CCK;
DE   Flags: Precursor;
GN   Name=CCK;
OS   Python molurus (Indian python).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Henophidia; Pythonidae; Python.
OX   NCBI_TaxID=51750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Jonson L., Wang T., Johnsen A.H.;
RT   "Gastrin and CCK in the Burmese python.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hypotensive neuropeptide that binds cholecystokinin receptors
CC       (CCKAR). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF521639; AAM77662.1; -; mRNA.
DR   AlphaFoldDB; Q8JHB9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   InterPro; IPR015499; CCK-like.
DR   InterPro; IPR001651; Gastrin/CCK.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PANTHER; PTHR10786; PTHR10786; 1.
DR   Pfam; PF00918; Gastrin; 1.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Hypotensive agent;
KW   Secreted; Signal; Sulfation.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..105
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000412829"
FT   PEPTIDE         106..113
FT                   /note="Cholecystokinin-8"
FT                   /id="PRO_0000412830"
FT   PROPEP          114..125
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000412831"
FT   MOD_RES         107
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         113
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  13822 MW;  99EC262E20DCBFEB CRC64;
     MYSGICSCLF LAVLSSSSLG QQISGSQHAN PAVTDLEQSL LENHRHTRIP TSGRPIQLVD
     GSIDQKANLG ALLAKYLQQA RRGSTGKASV MGLQNFDPTH RIKDRDYMGW MDFGRRSAEE
     YEYSS