CCL11_ARATH
ID CCL11_ARATH Reviewed; 416 AA.
AC Q8RWV3; A8MR67; O48710; Q94L33;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Cyclin-L1-1;
DE Short=CycL1;1;
DE AltName: Full=Arginine-rich cyclin 1;
DE Short=AtRCY1;
DE AltName: Full=Protein MODIFIER OF SNC1 12;
GN Name=CYCL1-1; Synonyms=MOS12, RCY1; OrderedLocusNames=At2g26430;
GN ORFNames=T9J22.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Landsberg erecta; TISSUE=Seedling;
RX PubMed=12047626; DOI=10.1046/j.1365-313x.2002.01311.x;
RA Forment J., Naranjo M.A., Roldan M., Serrano R., Vicente O.;
RT "Expression of Arabidopsis SR-like splicing proteins confers salt tolerance
RT to yeast and transgenic plants.";
RL Plant J. 30:511-519(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia; TISSUE=Rosette leaf;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15208425; DOI=10.1104/pp.104.040436;
RA Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA Ma H.;
RT "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT phylogenetic analysis of plant cyclin-like proteins.";
RL Plant Physiol. 135:1084-1099(2004).
RN [9]
RP FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH MOS4, AND SUBCELLULAR
RP LOCATION.
RX PubMed=22248079; DOI=10.1111/j.1365-313x.2012.04906.x;
RA Xu F., Xu S., Wiermer M., Zhang Y., Li X.;
RT "The cyclin L homolog MOS12 and the MOS4-associated complex are required
RT for the proper splicing of plant resistance genes.";
RL Plant J. 70:916-928(2012).
RN [10]
RP FUNCTION.
RX PubMed=23524848; DOI=10.1038/emboj.2013.49;
RA Zhang C.J., Zhou J.X., Liu J., Ma Z.Y., Zhang S.W., Dou K., Huang H.W.,
RA Cai T., Liu R., Zhu J.K., He X.J.;
RT "The splicing machinery promotes RNA-directed DNA methylation and
RT transcriptional silencing in Arabidopsis.";
RL EMBO J. 32:1128-1140(2013).
RN [11]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH CDKG1.
RX PubMed=24469829; DOI=10.1073/pnas.1318460111;
RA Zheng T., Nibau C., Phillips D.W., Jenkins G., Armstrong S.J., Doonan J.H.;
RT "CDKG1 protein kinase is essential for synapsis and male meiosis at high
RT ambient temperature in Arabidopsis thaliana.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:2182-2187(2014).
CC -!- FUNCTION: Cognate cyclin for CDKG1. Required for synapsis and male
CC meiosis, and for the proper splicing of specific resistance (R) genes.
CC Involved in regulation of DNA methylation and transcriptional
CC silencing. {ECO:0000269|PubMed:22248079, ECO:0000269|PubMed:23524848,
CC ECO:0000269|PubMed:24469829}.
CC -!- SUBUNIT: Forms a complex with CDKG1. Interacts with MOS4 and associates
CC with the spliceosome. {ECO:0000269|PubMed:22248079,
CC ECO:0000269|PubMed:24469829}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22248079}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8RWV3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8RWV3-2; Sequence=VSP_055305;
CC -!- DISRUPTION PHENOTYPE: Lethal, due to male sterility.
CC {ECO:0000269|PubMed:22248079, ECO:0000269|PubMed:24469829}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin L subfamily.
CC {ECO:0000305}.
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DR EMBL; AF249734; AAK49036.1; -; mRNA.
DR EMBL; AC002505; AAC14513.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC07836.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07837.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07838.1; -; Genomic_DNA.
DR EMBL; AY091085; AAM13905.1; -; mRNA.
DR EMBL; AY150419; AAN12964.1; -; mRNA.
DR EMBL; AK226505; BAE98647.1; -; mRNA.
DR EMBL; AK317155; BAH19841.1; -; mRNA.
DR EMBL; AY086218; AAM64296.1; -; mRNA.
DR PIR; T00976; T00976.
DR RefSeq; NP_001077962.1; NM_001084493.1. [Q8RWV3-2]
DR RefSeq; NP_001077963.1; NM_001084494.1. [Q8RWV3-2]
DR RefSeq; NP_565622.1; NM_128200.5. [Q8RWV3-1]
DR AlphaFoldDB; Q8RWV3; -.
DR SMR; Q8RWV3; -.
DR BioGRID; 2535; 3.
DR IntAct; Q8RWV3; 2.
DR STRING; 3702.AT2G26430.1; -.
DR PaxDb; Q8RWV3; -.
DR PRIDE; Q8RWV3; -.
DR ProteomicsDB; 239157; -. [Q8RWV3-1]
DR EnsemblPlants; AT2G26430.1; AT2G26430.1; AT2G26430. [Q8RWV3-1]
DR EnsemblPlants; AT2G26430.2; AT2G26430.2; AT2G26430. [Q8RWV3-2]
DR EnsemblPlants; AT2G26430.3; AT2G26430.3; AT2G26430. [Q8RWV3-2]
DR GeneID; 817183; -.
DR Gramene; AT2G26430.1; AT2G26430.1; AT2G26430. [Q8RWV3-1]
DR Gramene; AT2G26430.2; AT2G26430.2; AT2G26430. [Q8RWV3-2]
DR Gramene; AT2G26430.3; AT2G26430.3; AT2G26430. [Q8RWV3-2]
DR KEGG; ath:AT2G26430; -.
DR Araport; AT2G26430; -.
DR TAIR; locus:2066185; AT2G26430.
DR eggNOG; KOG0835; Eukaryota.
DR HOGENOM; CLU_022000_1_0_1; -.
DR InParanoid; Q8RWV3; -.
DR OrthoDB; 1519153at2759; -.
DR PhylomeDB; Q8RWV3; -.
DR PRO; PR:Q8RWV3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8RWV3; baseline and differential.
DR Genevisible; Q8RWV3; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009651; P:response to salt stress; IDA:TAIR.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; PTHR10026; 2.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Cyclin; Meiosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..416
FT /note="Cyclin-L1-1"
FT /id="PRO_0000287051"
FT REGION 286..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..55
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:19423640"
FT /id="VSP_055305"
FT CONFLICT 12
FT /note="S -> T (in Ref. 1; AAK49036)"
FT /evidence="ECO:0000305"
FT CONFLICT 46
FT /note="G -> E (in Ref. 4; AAM13905)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 416 AA; 47555 MW; 098209EA635598C5 CRC64;
MIYTAIDNFY LSDEQLKASP SRKDGIDETT EISLRIYGCD LIQEGGILLK LPQAVMATGQ
VLFQRFYCKK SLAKFDVKIV AASCVWLASK LEENPKKARQ VIIVFHRMEC RRENLPLEHL
DMYAKKFSEL KVELSRTERH ILKEMGFVCH VEHPHKFISN YLATLETPPE LRQEAWNLAN
DSLRTTLCVR FRSEVVACGV VYAAARRFQV PLPENPPWWK AFDADKSSID EVCRVLAHLY
SLPKAQYISV CKDGKPFTFS SRSGNSQGQS ATKDLLPGAG EAVDTKCTAG SANNDLKDGM
VTTPHEKATD SKKSGTESNS QPIVGDSSYE RSKVGDRERE SDREKERGRE RDRGRSHRGR
DSDRDSDRER DKLKDRSHHR SRDRLKDSGG HSDKSRHHSS RDRDYRDSSK DRRRHH
