CCL11_BOVIN
ID CCL11_BOVIN Reviewed; 97 AA.
AC Q9TTS6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Eotaxin;
DE AltName: Full=C-C motif chemokine 11;
DE AltName: Full=Small-inducible cytokine A11;
DE Flags: Precursor;
GN Name=CCL11;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=15916812; DOI=10.1016/j.vetimm.2005.03.013;
RA Vogel B., Klinder A., Sittig D., Aust G.;
RT "Bovine eotaxin (CCL11) -- an unusual member of the eotaxin group
RT -- attracts eosinophils in vitro but is not responsible for eosinophilia in
RT the ovary.";
RL Vet. Immunol. Immunopathol. 107:67-77(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In response to the presence of allergens, this protein
CC directly promotes the accumulation of eosinophils (a prominent feature
CC of allergic inflammatory reactions), but not lymphocytes, macrophages
CC or neutrophils (Probable). Attracts eosinophils in vitro but is not
CC responsible for eosinophilia in the ovary (PubMed:15916812). Binds to
CC CCR3 (By similarity). {ECO:0000250|UniProtKB:P51671,
CC ECO:0000269|PubMed:15916812, ECO:0000305|PubMed:15916812}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P97545}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AJ132003; CAB61617.1; -; mRNA.
DR EMBL; BC114735; AAI14736.1; -; mRNA.
DR RefSeq; NP_991342.1; NM_205773.2.
DR AlphaFoldDB; Q9TTS6; -.
DR SMR; Q9TTS6; -.
DR STRING; 9913.ENSBTAP00000005406; -.
DR PaxDb; Q9TTS6; -.
DR Ensembl; ENSBTAT00000005406; ENSBTAP00000005406; ENSBTAG00000004129.
DR GeneID; 404072; -.
DR KEGG; bta:404072; -.
DR CTD; 6356; -.
DR VEuPathDB; HostDB:ENSBTAG00000004129; -.
DR eggNOG; ENOG502S8M4; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_1_0_1; -.
DR InParanoid; Q9TTS6; -.
DR OMA; CFTLANR; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Reactome; R-BTA-380108; Chemokine receptors bind chemokines.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000004129; Expressed in caecum and 59 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031728; F:CCR3 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
DR GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007611; P:learning or memory; IEA:Ensembl.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0060763; P:mammary duct terminal end bud growth; IEA:Ensembl.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..97
FT /note="Eotaxin"
FT /id="PRO_0000244408"
FT CARBOHYD 94
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P51671"
FT DISULFID 32..57
FT /evidence="ECO:0000250|UniProtKB:P51671"
FT DISULFID 33..73
FT /evidence="ECO:0000250|UniProtKB:P51671"
SQ SEQUENCE 97 AA; 10965 MW; 9E65F23E1DDEB743 CRC64;
MKVSAVLLCL LLTATLCSIQ VLAQPASIPT ICCFNMSKKK ISIQRLQSYR KITSSKCPQK
AVIFNTKQNK KICVDPQEKW VQNAMEYLNQ KSQTLKS
