ID   CCL11_HORSE             Reviewed;         100 AA.
AC   Q9TTQ4;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Eotaxin;
DE   AltName: Full=C-C motif chemokine 11;
DE   AltName: Full=Small-inducible cytokine A11;
DE   Flags: Precursor;
GN   Name=CCL11; Synonyms=SCYA11;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11044560; DOI=10.1016/s0165-2427(00)00222-1;
RA   Benarafa C., Cunningham F.M., Hamblin A.S., Horohov D.W., Collins M.E.;
RT   "Cloning of equine chemokines eotaxin, monocyte chemoattractant protein
RT   (MCP)-1, MCP-2 and MCP-4, mRNA expression in tissues and induction by IL-4
RT   in dermal fibroblasts.";
RL   Vet. Immunol. Immunopathol. 76:283-298(2000).
CC   -!- FUNCTION: In response to the presence of allergens, this protein
CC       directly promotes the accumulation of eosinophils (a prominent feature
CC       of allergic inflammatory reactions), but not lymphocytes, macrophages
CC       or neutrophils (By similarity). Binds to CCR3 (By similarity).
CC       {ECO:0000250|UniProtKB:P48298, ECO:0000250|UniProtKB:P51671}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P97545}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ251188; CAB61624.1; -; mRNA.
DR   RefSeq; NP_001075340.1; NM_001081871.1.
DR   AlphaFoldDB; Q9TTQ4; -.
DR   SMR; Q9TTQ4; -.
DR   Ensembl; ENSECAT00000032414; ENSECAP00000031062; ENSECAG00000036715.
DR   GeneID; 100033949; -.
DR   KEGG; ecb:100033949; -.
DR   CTD; 6356; -.
DR   GeneTree; ENSGT01050000244851; -.
DR   InParanoid; Q9TTQ4; -.
DR   OrthoDB; 1575018at2759; -.
DR   Proteomes; UP000002281; Chromosome 11.
DR   Bgee; ENSECAG00000036715; Expressed in triceps brachii and 15 other tissues.
DR   ExpressionAtlas; Q9TTQ4; baseline.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..100
FT                   /note="Eotaxin"
FT                   /id="PRO_0000005194"
FT   CARBOHYD        94
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250|UniProtKB:P51671"
FT   DISULFID        32..57
FT                   /evidence="ECO:0000250|UniProtKB:P51671"
FT   DISULFID        33..73
FT                   /evidence="ECO:0000250|UniProtKB:P51671"
SQ   SEQUENCE   100 AA;  11247 MW;  11F08EC00E75D50B CRC64;
     MKVSAALLCL LLTTAAFSTQ VLAQPVSIST VCCFNVASRK ISFQRLQSYR KITSSKCPQK
     AVIFKTKQAK KICADPKQKW VQDAMKYLDE NSRTTKYSSF