CCL11_RAT
ID CCL11_RAT Reviewed; 97 AA.
AC P97545; O08780;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Eotaxin;
DE AltName: Full=C-C motif chemokine 11;
DE AltName: Full=Eosinophil chemotactic protein;
DE AltName: Full=Small-inducible cytokine A11;
DE Flags: Precursor;
GN Name=Ccl11; Synonyms=Scya11;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9396866; DOI=10.1007/s002510050345;
RA Williams C.M., Newton D.J., Wilson S.A., Williams T.J., Coleman J.W.,
RA Flanagan B.F.;
RT "Conserved structure and tissue expression of rat eotaxin.";
RL Immunogenetics 47:178-180(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC TISSUE=Lung;
RX PubMed=9458816; DOI=10.1152/ajplung.1998.274.1.l171;
RA Ishi Y., Shirato M., Nomura A., Sakamoto T., Uchida Y., Ohtsuka M.,
RA Sagai M., Hasegawa S.;
RT "Cloning of rat eotaxin: ozone inhalation increases mRNA and protein
RT expression in lungs of brown Norway rats.";
RL Am. J. Physiol. 274:L171-L176(1998).
CC -!- FUNCTION: In response to the presence of allergens, this protein
CC directly promotes the accumulation of eosinophils (a prominent feature
CC of allergic inflammatory reactions), but not lymphocytes, macrophages
CC or neutrophils (PubMed:9458816). Binds to CCR3 (By similarity).
CC {ECO:0000250|UniProtKB:P51671, ECO:0000269|PubMed:9458816}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9458816}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Y08358; CAA69645.1; -; mRNA.
DR EMBL; U96637; AAB65775.1; -; mRNA.
DR RefSeq; NP_062078.1; NM_019205.1.
DR AlphaFoldDB; P97545; -.
DR SMR; P97545; -.
DR STRING; 10116.ENSRNOP00000009756; -.
DR GlyGen; P97545; 1 site.
DR PaxDb; P97545; -.
DR Ensembl; ENSRNOT00000009756; ENSRNOP00000009756; ENSRNOG00000007335.
DR GeneID; 29397; -.
DR KEGG; rno:29397; -.
DR CTD; 6356; -.
DR RGD; 3644; Ccl11.
DR eggNOG; ENOG502S8M4; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_1_0_1; -.
DR InParanoid; P97545; -.
DR OMA; CFTLANR; -.
DR OrthoDB; 1575018at2759; -.
DR PhylomeDB; P97545; -.
DR TreeFam; TF334888; -.
DR PRO; PR:P97545; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000007335; Expressed in stomach and 14 other tissues.
DR Genevisible; P97545; RN.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031728; F:CCR3 chemokine receptor binding; ISO:RGD.
DR GO; GO:0008009; F:chemokine activity; IDA:RGD.
DR GO; GO:0046983; F:protein dimerization activity; ISO:RGD.
DR GO; GO:0048018; F:receptor ligand activity; ISO:RGD.
DR GO; GO:0007015; P:actin filament organization; IDA:RGD.
DR GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; ISO:RGD.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0002544; P:chronic inflammatory response; IEP:RGD.
DR GO; GO:0007010; P:cytoskeleton organization; ISO:RGD.
DR GO; GO:0048245; P:eosinophil chemotaxis; IDA:RGD.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IGI:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007611; P:learning or memory; ISO:RGD.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0060763; P:mammary duct terminal end bud growth; ISO:RGD.
DR GO; GO:0002551; P:mast cell chemotaxis; IDA:RGD.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0050768; P:negative regulation of neurogenesis; ISO:RGD.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; ISO:RGD.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:RGD.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:RGD.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; ISO:RGD.
DR GO; GO:0008360; P:regulation of cell shape; ISO:RGD.
DR GO; GO:0035962; P:response to interleukin-13; IEP:RGD.
DR GO; GO:0070670; P:response to interleukin-4; IEP:RGD.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..97
FT /note="Eotaxin"
FT /id="PRO_0000005198"
FT CARBOHYD 94
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P51671"
FT DISULFID 32..57
FT /evidence="ECO:0000250|UniProtKB:P51671"
FT DISULFID 33..73
FT /evidence="ECO:0000250|UniProtKB:P51671"
SQ SEQUENCE 97 AA; 10851 MW; 77375B4A038B3F6B CRC64;
MQLSTALLFL LLTATSFTSQ VLAHPGSIPT SCCFTMTSKK IPNTLLKSYK RITNNRCTLK
AIVFKTKLGK EICADPKKKW VQDATKHLDQ KLQTPKP
