ID   CCL17_CANLF             Reviewed;          99 AA.
AC   Q95N01;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=C-C motif chemokine 17;
DE   AltName: Full=CC chemokine TARC;
DE   AltName: Full=Small-inducible cytokine A17;
DE   AltName: Full=Thymus and activation-regulated chemokine;
DE   Flags: Precursor;
GN   Name=CCL17; Synonyms=TARC;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Thymus;
RX   PubMed=11642275; DOI=10.1292/jvms.63.1035;
RA   Maeda S., Mizuno T., Yamashita K., Kurata K., Masuda K., Ohno K.,
RA   Tsujimoto H.;
RT   "Molecular cloning of canine thymus and activation-regulated chemokine
RT   (TARC) gene and its expression in various tissues.";
RL   J. Vet. Med. Sci. 63:1035-1038(2001).
CC   -!- FUNCTION: Chemotactic factor for t lymphocytes but not monocytes or
CC       granulocytes. May play a role in T-cell development in thymus and in
CC       trafficking and activation of mature T-cells. Binds to CCR4 and CCR8
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in thymus, spleen, lymph node, lung and
CC       heart. {ECO:0000269|PubMed:11642275}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AB054642; BAB62131.1; -; mRNA.
DR   RefSeq; NP_001003051.1; NM_001003051.1.
DR   RefSeq; XP_005617272.1; XM_005617215.2.
DR   AlphaFoldDB; Q95N01; -.
DR   SMR; Q95N01; -.
DR   STRING; 9612.ENSCAFP00000012872; -.
DR   PaxDb; Q95N01; -.
DR   Ensembl; ENSCAFT00030005436; ENSCAFP00030004835; ENSCAFG00030002926.
DR   Ensembl; ENSCAFT00040021004; ENSCAFP00040018236; ENSCAFG00040011362.
DR   Ensembl; ENSCAFT00845005928; ENSCAFP00845004715; ENSCAFG00845003329.
DR   GeneID; 403586; -.
DR   KEGG; cfa:403586; -.
DR   CTD; 6361; -.
DR   VEuPathDB; HostDB:ENSCAFG00845003329; -.
DR   eggNOG; ENOG502SWZ0; Eukaryota.
DR   GeneTree; ENSGT00940000166352; -.
DR   HOGENOM; CLU_141716_6_0_1; -.
DR   InParanoid; Q95N01; -.
DR   OMA; ECCLDYF; -.
DR   OrthoDB; 1594204at2759; -.
DR   TreeFam; TF334888; -.
DR   Reactome; R-CFA-380108; Chemokine receptors bind chemokines.
DR   Proteomes; UP000002254; Chromosome 2.
DR   Bgee; ENSCAFG00000008754; Expressed in lymph node and 25 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..99
FT                   /note="C-C motif chemokine 17"
FT                   /id="PRO_0000005210"
FT   DISULFID        33..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   99 AA;  11052 MW;  6BA28EDDF857BE81 CRC64;
     MIPLKMLLLV TLLLGASLQV THAARGTNVG RECCLEYFKG AIPISRLTRW YKTSGECPKD
     AIVFVTVQGK SICSDPKDKR VKKAVRYLQR TWKGGPQES