ID   CCL17_FELCA             Reviewed;          99 AA.
AC   Q8I021;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=C-C motif chemokine 17;
DE   AltName: Full=CC chemokine TARC;
DE   AltName: Full=Small-inducible cytokine A17;
DE   AltName: Full=Thymus and activation-regulated chemokine;
DE   Flags: Precursor;
GN   Name=CCL17; Synonyms=TARC;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Thymus;
RX   PubMed=12655128; DOI=10.1292/jvms.65.275;
RA   Maeda S., Okayama T., Ohmori K., Masuda K., Ohno K., Tsujimoto H.;
RT   "Molecular cloning of the feline thymus and activation-regulated chemokine
RT   cDNA and its expression in lesional skin of cats with eosinophilic
RT   plaque.";
RL   J. Vet. Med. Sci. 65:275-278(2003).
CC   -!- FUNCTION: Chemotactic factor for t lymphocytes but not monocytes or
CC       granulocytes. May play a role in T-cell development in thymus and in
CC       trafficking and activation of mature T-cells. Binds to CCR4 and CCR8
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in thymus and also in spleen, lung, lymph
CC       node, kidney, small intestine, colon and skin.
CC       {ECO:0000269|PubMed:12655128}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AB084139; BAC22063.1; -; mRNA.
DR   RefSeq; NP_001009849.1; NM_001009849.1.
DR   AlphaFoldDB; Q8I021; -.
DR   SMR; Q8I021; -.
DR   STRING; 9685.ENSFCAP00000004337; -.
DR   GeneID; 493832; -.
DR   KEGG; fca:493832; -.
DR   CTD; 6361; -.
DR   eggNOG; ENOG502SWZ0; Eukaryota.
DR   InParanoid; Q8I021; -.
DR   OrthoDB; 1594204at2759; -.
DR   TreeFam; TF334888; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..99
FT                   /note="C-C motif chemokine 17"
FT                   /id="PRO_0000227015"
FT   DISULFID        33..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   99 AA;  11056 MW;  2E3FAD5976B6F749 CRC64;
     MMSLKLLLLV MLLLGASLQV THAARATNVG RECCLEYFKG AIPLRRLTGW YRTSGECSKD
     AIVFVTIHGK SICSDPKDTR VKKTVRYLQS IMNPVPQES