CCL17_HUMAN
ID CCL17_HUMAN Reviewed; 94 AA.
AC Q92583; A0N0Q9; Q2M287;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=C-C motif chemokine 17;
DE AltName: Full=CC chemokine TARC;
DE AltName: Full=Small-inducible cytokine A17;
DE AltName: Full=Thymus and activation-regulated chemokine;
DE Flags: Precursor;
GN Name=CCL17; Synonyms=SCYA17, TARC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 24-32.
RC TISSUE=Peripheral blood monocyte;
RX PubMed=8702936; DOI=10.1074/jbc.271.35.21514;
RA Imai T., Yoshida T., Baba M., Nishimura M., Kakizaki M., Yoshie O.;
RT "Molecular cloning of a novel T cell-directed CC chemokine expressed in
RT thymus by signal sequence trap using Epstein-Barr virus vector.";
RL J. Biol. Chem. 271:21514-21521(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B.,
RA Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O.,
RA Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I.,
RA Nickerson D.A.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA Adams M.D.;
RT "Genome duplications and other features in 12 Mb of DNA sequence from human
RT chromosome 16p and 16q.";
RL Genomics 60:295-308(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP RECEPTOR INTERACTION.
RX PubMed=9521068;
RX DOI=10.1002/(sici)1521-4141(199802)28:02<582::aid-immu582>3.0.co;2-a;
RA Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M.,
RA Menon S., Zlotnik A., Mantovani A., Santoni A., Napolitano M.;
RT "Identification of the CC chemokines TARC and macrophage inflammatory
RT protein-1 beta as novel functional ligands for the CCR8 receptor.";
RL Eur. J. Immunol. 28:582-588(1998).
RN [7]
RP FUNCTION.
RX PubMed=10540332;
RX DOI=10.1002/(sici)1521-4141(199910)29:10<3210::aid-immu3210>3.0.co;2-w;
RA Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W.,
RA Umland S.P.;
RT "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta
RT are not ligands for human CC-chemokine receptor 8.";
RL Eur. J. Immunol. 29:3210-3215(1999).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 24-94, AND DISULFIDE BONDS.
RX PubMed=12832759; DOI=10.1107/s0907444903009454;
RA Asojo O.A., Boulegue C., Hoover D.M., Lu W., Lubkowski J.;
RT "Structures of thymus and activation-regulated chemokine (TARC).";
RL Acta Crystallogr. D 59:1165-1173(2003).
CC -!- FUNCTION: Chemotactic factor for T-lymphocytes but not monocytes or
CC granulocytes. May play a role in T-cell development in thymus and in
CC trafficking and activation of mature T-cells. Binds to CCR4.
CC {ECO:0000269|PubMed:10540332}.
CC -!- INTERACTION:
CC Q92583; O00585: CCL21; NbExp=2; IntAct=EBI-16640146, EBI-953695;
CC Q92583; O15444: CCL25; NbExp=2; IntAct=EBI-16640146, EBI-7783341;
CC Q92583; Q9Y258: CCL26; NbExp=2; IntAct=EBI-16640146, EBI-7783416;
CC Q92583; Q9NRJ3: CCL28; NbExp=3; IntAct=EBI-16640146, EBI-7783254;
CC Q92583; P13501: CCL5; NbExp=9; IntAct=EBI-16640146, EBI-2848366;
CC Q92583; PRO_0000005175 [P13501]: CCL5; NbExp=6; IntAct=EBI-16640146, EBI-11712923;
CC Q92583; P51679: CCR4; NbExp=2; IntAct=EBI-16640146, EBI-7847466;
CC Q92583; P51681: CCR5; NbExp=2; IntAct=EBI-16640146, EBI-489374;
CC Q92583; P02776: PF4; NbExp=2; IntAct=EBI-16640146, EBI-2565740;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in thymus and at low
CC levels in the lung, colon and small intestine.
CC -!- INDUCTION: By phytohemagglutinin (PHA) in the peripheral blood
CC mononuclear cells and by cytokines in monocytes.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be a ligand for CCR8.
CC {ECO:0000305|PubMed:9521068}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=CCL17 entry;
CC URL="https://en.wikipedia.org/wiki/CCL17";
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DR EMBL; D43767; BAA07824.1; -; mRNA.
DR EMBL; EF064767; ABK41950.1; -; Genomic_DNA.
DR EMBL; AC004382; AAC24308.1; -; Genomic_DNA.
DR EMBL; CH471092; EAW82921.1; -; Genomic_DNA.
DR EMBL; BC069107; AAH69107.1; -; mRNA.
DR EMBL; BC112066; AAI12067.1; -; mRNA.
DR EMBL; BC112068; AAI12069.1; -; mRNA.
DR CCDS; CCDS10780.1; -.
DR RefSeq; NP_002978.1; NM_002987.2.
DR PDB; 1NR2; X-ray; 2.18 A; A/B=24-94.
DR PDB; 1NR4; X-ray; 1.72 A; A/B/C/D/E/F/G/H=24-94.
DR PDB; 5WK3; X-ray; 1.90 A; A/B/C/D=24-94.
DR PDB; 7S4N; X-ray; 1.65 A; B/D=24-94.
DR PDBsum; 1NR2; -.
DR PDBsum; 1NR4; -.
DR PDBsum; 5WK3; -.
DR PDBsum; 7S4N; -.
DR AlphaFoldDB; Q92583; -.
DR SMR; Q92583; -.
DR BioGRID; 112264; 11.
DR DIP; DIP-5842N; -.
DR IntAct; Q92583; 10.
DR STRING; 9606.ENSP00000219244; -.
DR ChEMBL; CHEMBL4295915; -.
DR iPTMnet; Q92583; -.
DR PhosphoSitePlus; Q92583; -.
DR BioMuta; CCL17; -.
DR DMDM; 3024711; -.
DR MassIVE; Q92583; -.
DR PaxDb; Q92583; -.
DR PeptideAtlas; Q92583; -.
DR PRIDE; Q92583; -.
DR ProteomicsDB; 75341; -.
DR ABCD; Q92583; 1 sequenced antibody.
DR Antibodypedia; 3752; 520 antibodies from 36 providers.
DR DNASU; 6361; -.
DR Ensembl; ENST00000219244.9; ENSP00000219244.4; ENSG00000102970.11.
DR Ensembl; ENST00000616880.1; ENSP00000480147.1; ENSG00000102970.11.
DR GeneID; 6361; -.
DR KEGG; hsa:6361; -.
DR MANE-Select; ENST00000219244.9; ENSP00000219244.4; NM_002987.3; NP_002978.1.
DR UCSC; uc002elj.1; human.
DR CTD; 6361; -.
DR DisGeNET; 6361; -.
DR GeneCards; CCL17; -.
DR HGNC; HGNC:10615; CCL17.
DR HPA; ENSG00000102970; Tissue enriched (lymphoid).
DR MIM; 601520; gene.
DR neXtProt; NX_Q92583; -.
DR OpenTargets; ENSG00000102970; -.
DR PharmGKB; PA35548; -.
DR VEuPathDB; HostDB:ENSG00000102970; -.
DR eggNOG; ENOG502SWZ0; Eukaryota.
DR GeneTree; ENSGT01050000244920; -.
DR HOGENOM; CLU_141716_6_0_1; -.
DR InParanoid; Q92583; -.
DR OMA; ECCLDYF; -.
DR OrthoDB; 1594204at2759; -.
DR PhylomeDB; Q92583; -.
DR TreeFam; TF334888; -.
DR PathwayCommons; Q92583; -.
DR Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR SignaLink; Q92583; -.
DR BioGRID-ORCS; 6361; 9 hits in 1060 CRISPR screens.
DR EvolutionaryTrace; Q92583; -.
DR GeneWiki; CCL17; -.
DR GenomeRNAi; 6361; -.
DR Pharos; Q92583; Tbio.
DR PRO; PR:Q92583; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q92583; protein.
DR Bgee; ENSG00000102970; Expressed in vermiform appendix and 117 other tissues.
DR Genevisible; Q92583; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031729; F:CCR4 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chemotaxis; Cytokine; Direct protein sequencing;
KW Disulfide bond; Inflammatory response; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:8702936"
FT CHAIN 24..94
FT /note="C-C motif chemokine 17"
FT /id="PRO_0000005211"
FT DISULFID 33..57
FT /evidence="ECO:0000269|PubMed:12832759"
FT DISULFID 34..73
FT /evidence="ECO:0000269|PubMed:12832759"
FT VARIANT 5
FT /note="K -> N (in dbSNP:rs34693308)"
FT /id="VAR_048708"
FT VARIANT 67
FT /note="V -> M (in dbSNP:rs34379253)"
FT /id="VAR_048709"
FT STRAND 27..29
FT /evidence="ECO:0007829|PDB:1NR4"
FT STRAND 32..36
FT /evidence="ECO:0007829|PDB:1NR4"
FT HELIX 44..46
FT /evidence="ECO:0007829|PDB:1NR4"
FT STRAND 47..52
FT /evidence="ECO:0007829|PDB:1NR4"
FT STRAND 57..59
FT /evidence="ECO:0007829|PDB:1NR4"
FT STRAND 62..66
FT /evidence="ECO:0007829|PDB:1NR4"
FT STRAND 71..74
FT /evidence="ECO:0007829|PDB:1NR4"
FT HELIX 79..90
FT /evidence="ECO:0007829|PDB:1NR4"
SQ SEQUENCE 94 AA; 10507 MW; 7959C56BA8FDAF08 CRC64;
MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW YQTSEDCSRD
AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS
