ID   CCL17_MACMU             Reviewed;          94 AA.
AC   Q8HYP9;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=C-C motif chemokine 17;
DE   AltName: Full=CC chemokine TARC;
DE   AltName: Full=Small-inducible cytokine A17;
DE   AltName: Full=Thymus and activation-regulated chemokine;
DE   Flags: Precursor;
GN   Name=CCL17; Synonyms=TARC;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12126650; DOI=10.1006/cyto.2002.0875;
RA   Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.;
RT   "Molecular cloning and sequencing of 25 different rhesus macaque chemokine
RT   cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families
RT   of chemokines.";
RL   Cytokine 18:140-148(2002).
CC   -!- FUNCTION: Chemotactic factor for T-lymphocytes but not monocytes or
CC       granulocytes. May play a role in T-cell development in thymus and in
CC       trafficking and activation of mature T-cells. Binds to CCR4 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AF449271; AAN76075.1; -; mRNA.
DR   RefSeq; NP_001028024.1; NM_001032852.1.
DR   AlphaFoldDB; Q8HYP9; -.
DR   SMR; Q8HYP9; -.
DR   STRING; 9544.ENSMMUP00000023940; -.
DR   GeneID; 574180; -.
DR   KEGG; mcc:574180; -.
DR   CTD; 6361; -.
DR   eggNOG; ENOG502SWZ0; Eukaryota.
DR   HOGENOM; CLU_141716_6_0_1; -.
DR   InParanoid; Q8HYP9; -.
DR   OrthoDB; 1594204at2759; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Inflammatory response; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..94
FT                   /note="C-C motif chemokine 17"
FT                   /id="PRO_0000244871"
SQ   SEQUENCE   94 AA;  10549 MW;  E07D40ED36199BFA CRC64;
     MAPLKMLALV ILLLGASLQH IHAARGTNVG RECCLKYFKG AIPLRKLKTW YQTSEDCSRD
     AIVFVTVQNK AICSDPNDKK VKKALKYLQS LERS