CCL19_MOUSE
ID CCL19_MOUSE Reviewed; 108 AA.
AC O70460;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=C-C motif chemokine 19;
DE AltName: Full=Epstein-Barr virus-induced molecule 1 ligand chemokine;
DE Short=EBI1 ligand chemokine;
DE Short=ELC;
DE AltName: Full=Small-inducible cytokine A19;
DE Flags: Precursor;
GN Name=Ccl19; Synonyms=Elc, Scya19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC TISSUE=Lymphoid tissue;
RX PubMed=9653094; DOI=10.1084/jem.188.1.181;
RA Ngo V.N., Tang H.L., Cyster J.G.;
RT "Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by
RT dendritic cells in lymphoid tissues and strongly attracts naive T cells and
RT activated B cells.";
RL J. Exp. Med. 188:181-191(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and
CC for CD8 T-cells and weakly attractive for resting B-cells and memory
CC (L-selectinlo) CD4 T-cells. May play a role in promoting encounters
CC between recirculating T-cells and dendritic cells and in the migration
CC of activated B-cells into the T-zone of secondary lymphoid tissues.
CC Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor
CC ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
CC -!- SUBUNIT: Interacts with TNFAIP6 (via Link domain).
CC {ECO:0000250|UniProtKB:Q99731}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Highly expressed by dendritic cells in mesenteric
CC and peripheral lymph nodes. Significant expression in spleen (T cell
CC zone or periarteriolar lymphatic sheath) and Peyer patches. Low
CC expression in thymus.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AF059208; AAC14661.1; -; mRNA.
DR EMBL; BC051472; AAH51472.1; -; mRNA.
DR CCDS; CCDS18080.1; -.
DR RefSeq; NP_036018.1; NM_011888.2.
DR RefSeq; XP_001472218.1; XM_001472168.6.
DR AlphaFoldDB; O70460; -.
DR SMR; O70460; -.
DR DIP; DIP-5920N; -.
DR STRING; 10090.ENSMUSP00000100022; -.
DR GlyGen; O70460; 1 site.
DR iPTMnet; O70460; -.
DR PhosphoSitePlus; O70460; -.
DR PaxDb; O70460; -.
DR PRIDE; O70460; -.
DR Antibodypedia; 11384; 498 antibodies from 33 providers.
DR DNASU; 24047; -.
DR Ensembl; ENSMUST00000102957; ENSMUSP00000100022; ENSMUSG00000071005.
DR GeneID; 24047; -.
DR KEGG; mmu:24047; -.
DR UCSC; uc008snx.1; mouse.
DR CTD; 6363; -.
DR MGI; MGI:1346316; Ccl19.
DR VEuPathDB; HostDB:ENSMUSG00000071005; -.
DR VEuPathDB; HostDB:ENSMUSG00000094661; -.
DR eggNOG; ENOG502SENW; Eukaryota.
DR GeneTree; ENSGT01050000244920; -.
DR HOGENOM; CLU_141716_3_1_1; -.
DR InParanoid; O70460; -.
DR OMA; PDQPWVG; -.
DR OrthoDB; 1542802at2759; -.
DR PhylomeDB; O70460; -.
DR TreeFam; TF334888; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 24047; 3 hits in 33 CRISPR screens.
DR ChiTaRS; Myl4; mouse.
DR PRO; PR:O70460; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; O70460; protein.
DR Bgee; ENSMUSG00000071005; Expressed in spleen and 44 other tissues.
DR ExpressionAtlas; O70460; baseline and differential.
DR Genevisible; O70460; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; ISO:MGI.
DR GO; GO:0031735; F:CCR10 chemokine receptor binding; ISO:MGI.
DR GO; GO:0031732; F:CCR7 chemokine receptor binding; IPI:BHF-UCL.
DR GO; GO:0008009; F:chemokine activity; IDA:BHF-UCL.
DR GO; GO:0042379; F:chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0048469; P:cell maturation; IDA:BHF-UCL.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0098586; P:cellular response to virus; ISO:MGI.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0002407; P:dendritic cell chemotaxis; IDA:BHF-UCL.
DR GO; GO:0001768; P:establishment of T cell polarity; ISS:BHF-UCL.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0001771; P:immunological synapse formation; IDA:BHF-UCL.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0097029; P:mature conventional dendritic cell differentiation; IDA:BHF-UCL.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002408; P:myeloid dendritic cell chemotaxis; ISS:BHF-UCL.
DR GO; GO:2000669; P:negative regulation of dendritic cell apoptotic process; ISS:BHF-UCL.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:2000147; P:positive regulation of cell motility; ISS:BHF-UCL.
DR GO; GO:0050921; P:positive regulation of chemotaxis; IDA:BHF-UCL.
DR GO; GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; IMP:BHF-UCL.
DR GO; GO:2000549; P:positive regulation of dendritic cell dendrite assembly; IDA:BHF-UCL.
DR GO; GO:0045807; P:positive regulation of endocytosis; IDA:BHF-UCL.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:BHF-UCL.
DR GO; GO:0010560; P:positive regulation of glycoprotein biosynthetic process; IDA:BHF-UCL.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IDA:BHF-UCL.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:BHF-UCL.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IDA:BHF-UCL.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IDA:BHF-UCL.
DR GO; GO:0046330; P:positive regulation of JNK cascade; ISS:BHF-UCL.
DR GO; GO:0043507; P:positive regulation of JUN kinase activity; IDA:BHF-UCL.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; ISS:BHF-UCL.
DR GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:BHF-UCL.
DR GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISS:BHF-UCL.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:BHF-UCL.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:BHF-UCL.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IDA:BHF-UCL.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:BHF-UCL.
DR GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; IDA:BHF-UCL.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:BHF-UCL.
DR GO; GO:0060491; P:regulation of cell projection assembly; IDA:BHF-UCL.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:BHF-UCL.
DR GO; GO:0071731; P:response to nitric oxide; ISS:BHF-UCL.
DR GO; GO:0034695; P:response to prostaglandin E; ISS:BHF-UCL.
DR GO; GO:0031295; P:T cell costimulation; IDA:BHF-UCL.
DR CDD; cd01119; Chemokine_CC_DCCL; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR034133; Chemokine_CC_DCCL.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 1: Evidence at protein level;
KW Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..108
FT /note="C-C motif chemokine 19"
FT /id="PRO_0000005215"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 33..59
FT /evidence="ECO:0000250"
FT DISULFID 34..75
FT /evidence="ECO:0000250"
SQ SEQUENCE 108 AA; 11911 MW; 0E2BC86D728319A7 CRC64;
MAPRVTPLLA FSLLVLWTFP APTLGGANDA EDCCLSVTQR PIPGNIVKAF RYLLNEDGCR
VPAVVFTTLR GYQLCAPPDQ PWVDRIIRRL KKSSAKNKGN STRRSPVS
