CCL22_MOUSE
ID CCL22_MOUSE Reviewed; 92 AA.
AC O88430;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=C-C motif chemokine 22;
DE AltName: Full=Activated B and dendritic cell-derived;
DE AltName: Full=CC chemokine ABCD-1;
DE AltName: Full=Small-inducible cytokine A22;
DE Flags: Precursor;
GN Name=Ccl22; Synonyms=Abcd1, Scya22;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=9687523; DOI=10.1084/jem.188.3.451;
RA Schaniel C., Pardali E., Sallusto F., Speletas M., Ruedl C., Shimizu T.,
RA Seidl T., Andersson J., Melchers F., Rolink A.G., Sideras P.;
RT "Activated murine B lymphocytes and dendritic cells produce a novel CC
RT chemokine which acts selectively on activated T cells.";
RL J. Exp. Med. 188:451-463(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Chemotactic for activated T-lymphocytes. May play an
CC important role in the collaboration of dendritic cells and B-
CC lymphocytes with T-cells in immune responses.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by activated splenic B-lymphocytes and
CC dendritic cells. Low expression in lung, thymocytes, lymph node, and
CC unstimulated splenic cells.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AF052505; AAC40200.1; -; mRNA.
DR EMBL; BC012658; AAH12658.1; -; mRNA.
DR CCDS; CCDS40441.1; -.
DR RefSeq; NP_033163.1; NM_009137.2.
DR AlphaFoldDB; O88430; -.
DR SMR; O88430; -.
DR STRING; 10090.ENSMUSP00000034231; -.
DR PhosphoSitePlus; O88430; -.
DR PaxDb; O88430; -.
DR PRIDE; O88430; -.
DR ProteomicsDB; 281328; -.
DR Antibodypedia; 15019; 523 antibodies from 33 providers.
DR DNASU; 20299; -.
DR Ensembl; ENSMUST00000034231; ENSMUSP00000034231; ENSMUSG00000031779.
DR GeneID; 20299; -.
DR KEGG; mmu:20299; -.
DR UCSC; uc009mww.1; mouse.
DR CTD; 6367; -.
DR MGI; MGI:1306779; Ccl22.
DR VEuPathDB; HostDB:ENSMUSG00000031779; -.
DR eggNOG; ENOG502SWZ0; Eukaryota.
DR GeneTree; ENSGT01050000244920; -.
DR HOGENOM; CLU_141716_4_2_1; -.
DR InParanoid; O88430; -.
DR OMA; CRDYIRH; -.
DR OrthoDB; 1575018at2759; -.
DR PhylomeDB; O88430; -.
DR TreeFam; TF334888; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR BioGRID-ORCS; 20299; 1 hit in 72 CRISPR screens.
DR PRO; PR:O88430; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; O88430; protein.
DR Bgee; ENSMUSG00000031779; Expressed in peripheral lymph node and 25 other tissues.
DR ExpressionAtlas; O88430; baseline and differential.
DR Genevisible; O88430; MM.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR030598; CCL22.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR PANTHER; PTHR12015:SF102; PTHR12015:SF102; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..92
FT /note="C-C motif chemokine 22"
FT /id="PRO_0000005228"
FT DISULFID 36..60
FT /evidence="ECO:0000250"
FT DISULFID 37..76
FT /evidence="ECO:0000250"
SQ SEQUENCE 92 AA; 10302 MW; 39859881CDAE07CA CRC64;
MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV KEFFWTSKSC
RKPGVVLITV KNRDICADPR QVWVKKLLHK LS
