CCL24_CANLF
ID CCL24_CANLF Reviewed; 119 AA.
AC Q68Y86;
DT 25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=C-C motif chemokine 24;
DE AltName: Full=Eosinophil chemotactic protein 2 {ECO:0000303|Ref.1};
DE Short=Eotaxin-2 {ECO:0000303|Ref.1};
DE AltName: Full=Small-inducible cytokine A24;
DE Flags: Precursor;
GN Name=CCL24 {ECO:0000303|Ref.1, ECO:0000303|Ref.2};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K.,
RA Tsujimoto H., Iwabuchi S.;
RT "Expression analysis of eosinophil chemotactic protein-2 (eotaxin-2/CCL24)
RT gene in canine atopic dermatitis.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Peters I.R., Peeters D., Clercx C., Day M.J.;
RT "Identification of coding sequences for canine monocyte chemotactic
RT protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine
RT receptor 3 (CCR3).";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chemotactic for resting T-lymphocytes, and eosinophils. Has
CC lower chemotactic activity for neutrophils but none for monocytes and
CC activated lymphocytes. Is a strong suppressor of colony formation by a
CC multipotential hematopoietic progenitor cell line. Binds to CCR3.
CC {ECO:0000250|UniProtKB:O00175}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00175}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AB162851; BAD36829.1; -; mRNA.
DR EMBL; AY675235; AAU14060.1; -; mRNA.
DR RefSeq; NP_001003967.1; NM_001003967.1.
DR AlphaFoldDB; Q68Y86; -.
DR SMR; Q68Y86; -.
DR STRING; 9612.ENSCAFP00000019742; -.
DR PaxDb; Q68Y86; -.
DR Ensembl; ENSCAFT00030018138; ENSCAFP00030015837; ENSCAFG00030009794.
DR GeneID; 445452; -.
DR KEGG; cfa:445452; -.
DR CTD; 6369; -.
DR eggNOG; ENOG502S6ZP; Eukaryota.
DR HOGENOM; CLU_141716_1_1_1; -.
DR InParanoid; Q68Y86; -.
DR OMA; KLPWVQK; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Proteomes; UP000002254; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031728; F:CCR3 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:2000418; P:positive regulation of eosinophil migration; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..119
FT /note="C-C motif chemokine 24"
FT /id="PRO_0000005231"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 33..58
FT /evidence="ECO:0000250|UniProtKB:O00175"
FT DISULFID 34..74
FT /evidence="ECO:0000250|UniProtKB:O00175"
SQ SEQUENCE 119 AA; 12987 MW; 4FB8D288F298306C CRC64;
MAGLATFVVS LLLVTLCAHC IDPAGSVSIP SSCCMFFISK KVPENRVVTY QLLNGSVCPK
AGVVFTTKKN QKFCGDPQLH WVQKLMKNIE ARRKKVSPGV RAMSTKALVQ RYPANSTSI
