CCL25_PIG
ID CCL25_PIG Reviewed; 151 AA.
AC Q4PR21;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=C-C motif chemokine 25;
DE AltName: Full=Chemokine ligand 25;
DE AltName: Full=Small-inducible cytokine A25;
DE Flags: Precursor;
GN Name=CCL25;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Berri M., Meurens F., Whale J., Brownlie R., Gerdts V., Chevaleyre C.,
RA Salmon H.;
RT "Sus scrofa chemokine (C-C motif) ligand 25 sequence.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potentially involved in T-cell development. Recombinant
CC protein shows chemotactic activity on thymocytes, macrophages, THP-1
CC cells, and dendritics cells but is inactive on peripheral blood
CC lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine
CC receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2)
CC to ACKR4 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; DQ061157; AAY67883.1; -; mRNA.
DR RefSeq; NP_001020385.1; NM_001025214.1.
DR RefSeq; XP_005661315.1; XM_005661258.2.
DR RefSeq; XP_005661316.1; XM_005661259.2.
DR AlphaFoldDB; Q4PR21; -.
DR SMR; Q4PR21; -.
DR STRING; 9823.ENSSSCP00000014444; -.
DR PaxDb; Q4PR21; -.
DR PeptideAtlas; Q4PR21; -.
DR PRIDE; Q4PR21; -.
DR Ensembl; ENSSSCT00000047746; ENSSSCP00000045987; ENSSSCG00000013593.
DR Ensembl; ENSSSCT00005033508; ENSSSCP00005020450; ENSSSCG00005021195.
DR Ensembl; ENSSSCT00015089639; ENSSSCP00015036595; ENSSSCG00015066934.
DR Ensembl; ENSSSCT00025021545; ENSSSCP00025008865; ENSSSCG00025016057.
DR Ensembl; ENSSSCT00030010273; ENSSSCP00030004412; ENSSSCG00030007657.
DR Ensembl; ENSSSCT00035105717; ENSSSCP00035045450; ENSSSCG00035077557.
DR Ensembl; ENSSSCT00040005039; ENSSSCP00040001726; ENSSSCG00040003963.
DR Ensembl; ENSSSCT00045058411; ENSSSCP00045040833; ENSSSCG00045034044.
DR Ensembl; ENSSSCT00050068409; ENSSSCP00050029349; ENSSSCG00050050284.
DR Ensembl; ENSSSCT00055024658; ENSSSCP00055019567; ENSSSCG00055012540.
DR Ensembl; ENSSSCT00060024110; ENSSSCP00060010114; ENSSSCG00060017990.
DR Ensembl; ENSSSCT00065077245; ENSSSCP00065033569; ENSSSCG00065056447.
DR Ensembl; ENSSSCT00070051060; ENSSSCP00070043180; ENSSSCG00070025542.
DR GeneID; 448799; -.
DR KEGG; ssc:448799; -.
DR CTD; 6370; -.
DR VGNC; VGNC:99612; CCL25.
DR eggNOG; ENOG502S8D1; Eukaryota.
DR GeneTree; ENSGT01010000222539; -.
DR HOGENOM; CLU_113773_0_0_1; -.
DR InParanoid; Q4PR21; -.
DR OMA; WAPAVHA; -.
DR OrthoDB; 1542802at2759; -.
DR TreeFam; TF353160; -.
DR Reactome; R-SSC-380108; Chemokine receptors bind chemokines.
DR Reactome; R-SSC-418594; G alpha (i) signalling events.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Chromosome 2.
DR Bgee; ENSSSCG00000013593; Expressed in duodenum and 42 other tissues.
DR ExpressionAtlas; Q4PR21; baseline and differential.
DR Genevisible; Q4PR21; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031735; F:CCR10 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0042379; F:chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:1903237; P:negative regulation of leukocyte tethering or rolling; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..151
FT /note="C-C motif chemokine 25"
FT /id="PRO_0000231040"
FT REGION 93..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 30..58
FT /evidence="ECO:0000250"
FT DISULFID 31..75
FT /evidence="ECO:0000250"
SQ SEQUENCE 151 AA; 16878 MW; 01E22AF59AFFAC57 CRC64;
MRPWLLACLV ACFVGAWAPA IHAQGAFEDC CLAYHSHIKW RLLRRAHSYQ RQDVSGSCNL
PAVIFFFPQK DKMVCGKPGA KWVQFGMKIL DNRNKKDSKP HHSGRRFFQG PQSGVRKLSS
GTSRPLLLKF SGPTRSSKRK ASLLTTAIPG P
