CCL26_CANLF
ID CCL26_CANLF Reviewed; 94 AA.
AC Q64H35;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=C-C motif chemokine 26 {ECO:0000303|Ref.1};
DE AltName: Full=Eotaxin-3 {ECO:0000303|Ref.1};
DE AltName: Full=Small-inducible cytokine A26;
DE Flags: Precursor;
GN Name=CCL26 {ECO:0000303|Ref.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Peters I.R., Peeters D., Clercx C., Day M.J.;
RT "Identification of coding sequences for canine monocyte chemotactic
RT protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine
RT receptor 3 (CCR3).";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chemoattractant for eosinophils and basophils. Acts as a
CC ligand for C-C chemokine receptor CCR3 which triggers Ca(2+)
CC mobilization in eosinophils. Also acts as a ligand for CX3C chemokine
CC receptor CX3CR1, inducing cell chemotaxis.
CC {ECO:0000250|UniProtKB:Q9Y258}.
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q9Y258}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9Y258}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AY675236; AAU14061.1; -; mRNA.
DR RefSeq; NP_001005253.1; NM_001005253.1.
DR AlphaFoldDB; Q64H35; -.
DR SMR; Q64H35; -.
DR STRING; 9612.ENSCAFP00000040578; -.
DR PaxDb; Q64H35; -.
DR Ensembl; ENSCAFT00040024304; ENSCAFP00040021118; ENSCAFG00040013153.
DR Ensembl; ENSCAFT00845007282; ENSCAFP00845005786; ENSCAFG00845004038.
DR GeneID; 448789; -.
DR KEGG; cfa:448789; -.
DR CTD; 10344; -.
DR VEuPathDB; HostDB:ENSCAFG00845004038; -.
DR eggNOG; ENOG502T082; Eukaryota.
DR GeneTree; ENSGT01050000244920; -.
DR HOGENOM; CLU_141716_6_0_1; -.
DR InParanoid; Q64H35; -.
DR OMA; CAHPKEK; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Proteomes; UP000002254; Chromosome 6.
DR Bgee; ENSCAFG00000032573; Expressed in jejunum and 16 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031728; F:CCR3 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0031737; F:CX3C chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0050921; P:positive regulation of chemotaxis; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0010818; P:T cell chemotaxis; IEA:Ensembl.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..94
FT /note="C-C motif chemokine 26"
FT /id="PRO_0000005237"
FT DISULFID 33..57
FT /evidence="ECO:0000250|UniProtKB:Q9Y258"
FT DISULFID 34..73
FT /evidence="ECO:0000250|UniProtKB:Q9Y258"
SQ SEQUENCE 94 AA; 11012 MW; FAC1A201F0981C29 CRC64;
MKSFPVAFLV LLIFILSVHR GVTTRGSDVA KFCCFQYSHK ILPWKWIQSY KFTRSSCSQQ
AVIFTTKKGH KVCAQPKEKW VQRYIALLRE QQQS
