ID   CCL28_MOUSE             Reviewed;         130 AA.
AC   Q9JIL2;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=C-C motif chemokine 28;
DE   AltName: Full=Small-inducible cytokine A28;
DE   Flags: Precursor;
GN   Name=Ccl28; Synonyms=Scya28;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND RECEPTOR INTERACTION.
RC   TISSUE=Kidney;
RX   PubMed=10781587; DOI=10.1074/jbc.m001461200;
RA   Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D.,
RA   Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J.,
RA   Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A.;
RT   "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).";
RL   J. Biol. Chem. 275:22313-22323(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Chemotactic for resting CD4, CD8 T-cells and eosinophils (By
CC       similarity). Binds to CCR10 and induces calcium mobilization in a dose-
CC       dependent manner. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in testis, epithelial cells of
CC       normal colon, kidney, Peyer patches, lymph nodes. Also found in lower
CC       levels in brain, spleen and lung.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AF220238; AAF87206.1; -; mRNA.
DR   EMBL; BC055864; AAH55864.1; -; mRNA.
DR   CCDS; CCDS56900.1; -.
DR   RefSeq; NP_064675.1; NM_020279.3.
DR   AlphaFoldDB; Q9JIL2; -.
DR   SMR; Q9JIL2; -.
DR   IntAct; Q9JIL2; 1.
DR   MINT; Q9JIL2; -.
DR   STRING; 10090.ENSMUSP00000096847; -.
DR   GlyGen; Q9JIL2; 1 site.
DR   PhosphoSitePlus; Q9JIL2; -.
DR   PaxDb; Q9JIL2; -.
DR   PRIDE; Q9JIL2; -.
DR   ProteomicsDB; 265375; -.
DR   Antibodypedia; 23245; 345 antibodies from 31 providers.
DR   DNASU; 56838; -.
DR   Ensembl; ENSMUST00000099241; ENSMUSP00000096847; ENSMUSG00000074715.
DR   GeneID; 56838; -.
DR   KEGG; mmu:56838; -.
DR   UCSC; uc007sal.1; mouse.
DR   CTD; 56477; -.
DR   MGI; MGI:1861731; Ccl28.
DR   VEuPathDB; HostDB:ENSMUSG00000074715; -.
DR   eggNOG; ENOG502SVUE; Eukaryota.
DR   GeneTree; ENSGT00530000063923; -.
DR   HOGENOM; CLU_2003113_0_0_1; -.
DR   InParanoid; Q9JIL2; -.
DR   OMA; HVIKQWM; -.
DR   OrthoDB; 1574270at2759; -.
DR   PhylomeDB; Q9JIL2; -.
DR   TreeFam; TF337014; -.
DR   Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   BioGRID-ORCS; 56838; 3 hits in 71 CRISPR screens.
DR   ChiTaRS; Ccl28; mouse.
DR   PRO; PR:Q9JIL2; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q9JIL2; protein.
DR   Bgee; ENSMUSG00000074715; Expressed in lacrimal gland and 101 other tissues.
DR   Genevisible; Q9JIL2; MM.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0030141; C:secretory granule; ISO:MGI.
DR   GO; GO:0008009; F:chemokine activity; IDA:UniProtKB.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
DR   GO; GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
DR   GO; GO:0051715; P:cytolysis in another organism; ISO:MGI.
DR   GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR   GO; GO:1903237; P:negative regulation of leukocyte tethering or rolling; ISO:MGI.
DR   GO; GO:0001954; P:positive regulation of cell-matrix adhesion; ISO:MGI.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:MGI.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   Pfam; PF00048; IL8; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   1: Evidence at protein level;
KW   Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..130
FT                   /note="C-C motif chemokine 28"
FT                   /id="PRO_0000005243"
FT   REGION          92..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..130
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        78
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        30..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   130 AA;  14570 MW;  6F3B909A4F97F013 CRC64;
     MQQAGLTLMA VAVCVAFQTS EAILPMASSC CTEVSHHVSG RLLERVSSCS IQRADGDCDL
     AAVILHVKRR RICISPHNRT LKQWMRASEV KKNGRENVCS GKKQPSRKDR KGHTTRKHRT
     RGTHRHEASR