CCL2_MACMU
ID CCL2_MACMU Reviewed; 99 AA.
AC P61275; Q9MYN4;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=C-C motif chemokine 2;
DE AltName: Full=Monocyte chemoattractant protein 1;
DE AltName: Full=Monocyte chemotactic protein 1;
DE Short=MCP-1;
DE AltName: Full=Small-inducible cytokine A2;
DE Flags: Precursor;
GN Name=CCL2; Synonyms=MCP1, SCYA2;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Studer C., Urfer R.;
RT "Cloning and expression of rhesus monkey monocyte chemoattractant protein-
RT 1.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a ligand for C-C chemokine receptor CCR2 (By
CC similarity). Signals through binding and activation of CCR2 and induces
CC a strong chemotactic response and mobilization of intracellular calcium
CC ions (By similarity). Exhibits a chemotactic activity for monocytes and
CC basophils but not neutrophils or eosinophils (By similarity). Plays an
CC important role in mediating peripheral nerve injury-induced neuropathic
CC pain (By similarity). Increases NMDA-mediated synaptic transmission in
CC both dopamine D1 and D2 receptor-containing neurons, which may be
CC caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By
CC similarity). {ECO:0000250|UniProtKB:P10148,
CC ECO:0000250|UniProtKB:P13500}.
CC -!- SUBUNIT: Monomer or homodimer; in equilibrium. Is tethered on
CC endothelial cells by glycosaminoglycan (GAG) side chains of
CC proteoglycans. Interacts with TNFAIP6 (via Link domain).
CC {ECO:0000250|UniProtKB:P13500}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13500}.
CC -!- PTM: Processing at the N-terminus can regulate receptor and target cell
CC selectivity (By similarity). Deletion of the N-terminal residue
CC converts it from an activator of basophil to an eosinophil
CC chemoattractant (By similarity). {ECO:0000250|UniProtKB:P13500}.
CC -!- PTM: N-Glycosylated. {ECO:0000250|UniProtKB:P13500}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AF255343; AAF67756.1; -; mRNA.
DR RefSeq; NP_001027993.1; NM_001032821.1.
DR AlphaFoldDB; P61275; -.
DR SMR; P61275; -.
DR STRING; 9544.ENSMMUP00000000391; -.
DR GeneID; 574138; -.
DR KEGG; mcc:574138; -.
DR CTD; 6347; -.
DR eggNOG; ENOG502S6ZP; Eukaryota.
DR HOGENOM; CLU_141716_1_0_1; -.
DR InParanoid; P61275; -.
DR OMA; PITCCYT; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; ISS:UniProtKB.
DR GO; GO:0019233; P:sensory perception of pain; ISS:UniProtKB.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Inflammatory response;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..99
FT /note="C-C motif chemokine 2"
FT /id="PRO_0000005148"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P13500"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 34..59
FT /evidence="ECO:0000250"
FT DISULFID 35..75
FT /evidence="ECO:0000250"
SQ SEQUENCE 99 AA; 11007 MW; 433CB88C64EE7A4F CRC64;
MKVSAALLCL LLIAATFSPQ GLAQPDAINA PVTCCYNFTN RKISVQRLAS YRRITSSKCP
KEAVIFKTIV AKEICADPKQ KWVQDSMDHL DKQIQTPKP
