CCL2_PIG
ID CCL2_PIG Reviewed; 99 AA.
AC P42831;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=C-C motif chemokine 2;
DE AltName: Full=Monocyte chemoattractant protein 1;
DE AltName: Full=Monocyte chemotactic protein 1;
DE Short=MCP-1;
DE AltName: Full=Small-inducible cytokine A2;
DE Flags: Precursor;
GN Name=CCL2; Synonyms=SCYA2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7510962; DOI=10.1006/bbrc.1994.1323;
RA Hosang K., Knoke I., Klaudiny J., Wempe F., Wuttke W., Scheit K.H.;
RT "Porcine luteal cells express monocyte chemoattractant protein-1 (MCP-1):
RT analysis by polymerase chain reaction and cDNA cloning.";
RL Biochem. Biophys. Res. Commun. 199:962-968(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Zach O.R.F.;
RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a ligand for C-C chemokine receptor CCR2 (By
CC similarity). Signals through binding and activation of CCR2 and induces
CC a strong chemotactic response and mobilization of intracellular calcium
CC ions (By similarity). Exhibits a chemotactic activity for monocytes and
CC basophils but not neutrophils or eosinophils (By similarity). Plays an
CC important role in mediating peripheral nerve injury-induced neuropathic
CC pain (By similarity). Increases NMDA-mediated synaptic transmission in
CC both dopamine D1 and D2 receptor-containing neurons, which may be
CC caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By
CC similarity). {ECO:0000250|UniProtKB:P10148,
CC ECO:0000250|UniProtKB:P13500}.
CC -!- SUBUNIT: Monomer or homodimer; in equilibrium. Is tethered on
CC endothelial cells by glycosaminoglycan (GAG) side chains of
CC proteoglycans. Interacts with TNFAIP6 (via Link domain).
CC {ECO:0000250|UniProtKB:P13500}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13500}.
CC -!- PTM: Processing at the N-terminus can regulate receptor and target cell
CC selectivity (By similarity). Deletion of the N-terminal residue
CC converts it from an activator of basophil to an eosinophil
CC chemoattractant (By similarity). {ECO:0000250|UniProtKB:P13500}.
CC -!- PTM: N-Glycosylated. {ECO:0000250|UniProtKB:P13500}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; Z48479; CAA88370.1; -; mRNA.
DR EMBL; X79416; CAA55945.1; -; mRNA.
DR PIR; JC2136; JC2136.
DR RefSeq; NP_999379.1; NM_214214.1.
DR AlphaFoldDB; P42831; -.
DR SMR; P42831; -.
DR STRING; 9823.ENSSSCP00000018779; -.
DR PaxDb; P42831; -.
DR Ensembl; ENSSSCT00000019290; ENSSSCP00000018779; ENSSSCG00000017723.
DR Ensembl; ENSSSCT00005020545; ENSSSCP00005012371; ENSSSCG00005013096.
DR Ensembl; ENSSSCT00015014476; ENSSSCP00015005616; ENSSSCG00015010935.
DR Ensembl; ENSSSCT00030075613; ENSSSCP00030034551; ENSSSCG00030054240.
DR Ensembl; ENSSSCT00035084936; ENSSSCP00035035342; ENSSSCG00035063168.
DR Ensembl; ENSSSCT00040012972; ENSSSCP00040004899; ENSSSCG00040010004.
DR Ensembl; ENSSSCT00045031268; ENSSSCP00045021669; ENSSSCG00045018363.
DR Ensembl; ENSSSCT00050053082; ENSSSCP00050022292; ENSSSCG00050039348.
DR Ensembl; ENSSSCT00055016609; ENSSSCP00055013103; ENSSSCG00055008496.
DR Ensembl; ENSSSCT00060077021; ENSSSCP00060033287; ENSSSCG00060056544.
DR Ensembl; ENSSSCT00065092116; ENSSSCP00065040308; ENSSSCG00065067117.
DR Ensembl; ENSSSCT00070015610; ENSSSCP00070012916; ENSSSCG00070008075.
DR GeneID; 397422; -.
DR KEGG; ssc:397422; -.
DR CTD; 6347; -.
DR eggNOG; ENOG502S6ZP; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_1_0_1; -.
DR InParanoid; P42831; -.
DR OMA; PITCCYT; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Reactome; R-SSC-380108; Chemokine receptors bind chemokines.
DR Proteomes; UP000008227; Chromosome 12.
DR Proteomes; UP000314985; Chromosome 12.
DR Bgee; ENSSSCG00000017723; Expressed in endocardial endothelium and 42 other tissues.
DR ExpressionAtlas; P42831; baseline and differential.
DR Genevisible; P42831; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0043615; P:astrocyte cell migration; IEA:Ensembl.
DR GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0048246; P:macrophage chemotaxis; IEA:Ensembl.
DR GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0034351; P:negative regulation of glial cell apoptotic process; IEA:Ensembl.
DR GO; GO:2000502; P:negative regulation of natural killer cell chemotaxis; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1905563; P:negative regulation of vascular endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0090280; P:positive regulation of calcium ion import; IEA:Ensembl.
DR GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; ISS:UniProtKB.
DR GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0019233; P:sensory perception of pain; ISS:UniProtKB.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..99
FT /note="C-C motif chemokine 2"
FT /id="PRO_0000005153"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P13500"
FT DISULFID 34..59
FT /evidence="ECO:0000250"
FT DISULFID 35..75
FT /evidence="ECO:0000250"
SQ SEQUENCE 99 AA; 10976 MW; 4C0AC6278D4F0A09 CRC64;
MKVSAALLCL LLTAATFCTQ VLAQPDAINS PVTCCYTLTS KKISMQRLMS YRRVTSSKCP
KEAVIFKTIA GKEICAEPKQ KWVQDSISHL DKKNQTPKP
