ID   CCL3_BOVIN              Reviewed;          93 AA.
AC   Q8SQA6;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=C-C motif chemokine 3;
DE   AltName: Full=Macrophage inflammatory protein 1-alpha;
DE            Short=MIP-1-alpha;
DE   AltName: Full=Small-inducible cytokine A3;
DE   Flags: Precursor;
GN   Name=CCL3; Synonyms=SCYA3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Werling D.;
RT   "Role of chemokines in RSV infection.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds
CC       to CCR1, CCR4 and CCR5 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AY077840; AAL78060.1; -; mRNA.
DR   RefSeq; NP_776936.1; NM_174511.2.
DR   AlphaFoldDB; Q8SQA6; -.
DR   SMR; Q8SQA6; -.
DR   STRING; 9913.ENSBTAP00000035305; -.
DR   PaxDb; Q8SQA6; -.
DR   GeneID; 282170; -.
DR   KEGG; bta:282170; -.
DR   CTD; 6348; -.
DR   eggNOG; ENOG502SAF0; Eukaryota.
DR   InParanoid; Q8SQA6; -.
DR   OrthoDB; 1575018at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0004698; F:calcium-dependent protein kinase C activity; ISS:UniProtKB.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
DR   GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR   GO; GO:0016301; F:kinase activity; ISS:UniProtKB.
DR   GO; GO:0016004; F:phospholipase activator activity; ISS:UniProtKB.
DR   GO; GO:0004672; F:protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0043615; P:astrocyte cell migration; ISS:UniProtKB.
DR   GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR   GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
DR   GO; GO:0001775; P:cell activation; ISS:UniProtKB.
DR   GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; ISS:UniProtKB.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR   GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0048245; P:eosinophil chemotaxis; ISS:UniProtKB.
DR   GO; GO:0043308; P:eosinophil degranulation; ISS:UniProtKB.
DR   GO; GO:0006887; P:exocytosis; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0071621; P:granulocyte chemotaxis; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; ISS:UniProtKB.
DR   GO; GO:0048246; P:macrophage chemotaxis; ISS:UniProtKB.
DR   GO; GO:0000165; P:MAPK cascade; ISS:UniProtKB.
DR   GO; GO:0002548; P:monocyte chemotaxis; ISS:UniProtKB.
DR   GO; GO:0043922; P:negative regulation by host of viral transcription; ISS:UniProtKB.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
DR   GO; GO:0030593; P:neutrophil chemotaxis; ISS:UniProtKB.
DR   GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
DR   GO; GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB.
DR   GO; GO:0050850; P:positive regulation of calcium-mediated signaling; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB.
DR   GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISS:UniProtKB.
DR   GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
DR   GO; GO:0043491; P:protein kinase B signaling; ISS:UniProtKB.
DR   GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0050795; P:regulation of behavior; ISS:UniProtKB.
DR   GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0070723; P:response to cholesterol; ISS:UniProtKB.
DR   GO; GO:0009636; P:response to toxic substance; ISS:UniProtKB.
DR   GO; GO:0023052; P:signaling; ISS:UniProtKB.
DR   GO; GO:0010818; P:T cell chemotaxis; ISS:UniProtKB.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250|UniProtKB:P10147"
FT   CHAIN           25..93
FT                   /note="C-C motif chemokine 3"
FT                   /id="PRO_0000005154"
FT   DISULFID        34..58
FT                   /evidence="ECO:0000250|UniProtKB:P10147"
FT   DISULFID        35..74
FT                   /evidence="ECO:0000250|UniProtKB:P10147"
SQ   SEQUENCE   93 AA;  10118 MW;  1266BFBFCEE5E8E9 CRC64;
     MKVAVAALAV LLCAMALCSQ VFSAPFGADT PTACCFSYVA RQLSRKIVAD YFETSSQCSK
     PGVIFQTKKG RQVCANPTED WVQEYITDLE LNA