CCL3_MACMU
ID CCL3_MACMU Reviewed; 92 AA.
AC Q8HYQ3; Q8HYN4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=C-C motif chemokine 3;
DE AltName: Full=Macrophage inflammatory protein 1-alpha;
DE Short=MIP-1-alpha;
DE AltName: Full=Small-inducible cytokine A3;
DE Flags: Precursor;
GN Name=CCL3; Synonyms=MIP1A;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12126650; DOI=10.1006/cyto.2002.0875;
RA Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.;
RT "Molecular cloning and sequencing of 25 different rhesus macaque chemokine
RT cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families
RT of chemokines.";
RL Cytokine 18:140-148(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 30-85.
RX PubMed=12079558; DOI=10.1089/088922202760019329;
RA Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L.,
RA Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.;
RT "Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time
RT reverse transcriptase-polymerase chain reaction: variations in expression
RT during chronic primate lentivirus infection.";
RL AIDS Res. Hum. Retroviruses 18:627-639(2002).
CC -!- FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds
CC to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors
CC produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-
CC dependent inhibition of different strains of HIV-1, HIV-2, and simian
CC immunodeficiency virus (SIV) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Self-associates. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AF449266; AAN76070.1; -; mRNA.
DR EMBL; AF457195; AAN76985.1; -; mRNA.
DR RefSeq; NP_001029372.1; NM_001034200.1.
DR AlphaFoldDB; Q8HYQ3; -.
DR SMR; Q8HYQ3; -.
DR STRING; 9544.ENSMMUP00000001262; -.
DR Ensembl; ENSMMUT00000099823; ENSMMUP00000066321; ENSMMUG00000062832.
DR GeneID; 619514; -.
DR KEGG; mcc:619514; -.
DR CTD; 6348; -.
DR VEuPathDB; HostDB:ENSMMUG00000062832; -.
DR eggNOG; ENOG502SAF0; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_4_0_1; -.
DR InParanoid; Q8HYQ3; -.
DR OMA; MKTSQRC; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Proteomes; UP000006718; Chromosome 16.
DR Bgee; ENSMMUG00000062832; Expressed in spleen and 10 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0004698; F:calcium-dependent protein kinase C activity; ISS:UniProtKB.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
DR GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR GO; GO:0016301; F:kinase activity; ISS:UniProtKB.
DR GO; GO:0016004; F:phospholipase activator activity; ISS:UniProtKB.
DR GO; GO:0004672; F:protein kinase activity; ISS:UniProtKB.
DR GO; GO:0043615; P:astrocyte cell migration; ISS:UniProtKB.
DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0001775; P:cell activation; ISS:UniProtKB.
DR GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071407; P:cellular response to organic cyclic compound; ISS:UniProtKB.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0048245; P:eosinophil chemotaxis; ISS:UniProtKB.
DR GO; GO:0043308; P:eosinophil degranulation; ISS:UniProtKB.
DR GO; GO:0006887; P:exocytosis; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0071621; P:granulocyte chemotaxis; ISS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0048247; P:lymphocyte chemotaxis; ISS:UniProtKB.
DR GO; GO:0048246; P:macrophage chemotaxis; ISS:UniProtKB.
DR GO; GO:0000165; P:MAPK cascade; ISS:UniProtKB.
DR GO; GO:0002548; P:monocyte chemotaxis; ISS:UniProtKB.
DR GO; GO:0043922; P:negative regulation by host of viral transcription; ISS:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
DR GO; GO:0030593; P:neutrophil chemotaxis; ISS:UniProtKB.
DR GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB.
DR GO; GO:0050850; P:positive regulation of calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB.
DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISS:UniProtKB.
DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
DR GO; GO:0043491; P:protein kinase B signaling; ISS:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR GO; GO:0050795; P:regulation of behavior; ISS:UniProtKB.
DR GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
DR GO; GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB.
DR GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0070723; P:response to cholesterol; ISS:UniProtKB.
DR GO; GO:0009636; P:response to toxic substance; ISS:UniProtKB.
DR GO; GO:0023052; P:signaling; ISS:UniProtKB.
DR GO; GO:0010818; P:T cell chemotaxis; ISS:UniProtKB.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..92
FT /note="C-C motif chemokine 3"
FT /id="PRO_0000042848"
FT SITE 40
FT /note="Involved in GAG binding"
FT /evidence="ECO:0000250"
FT SITE 68
FT /note="Involved in GAG binding"
FT /evidence="ECO:0000250"
FT SITE 70
FT /note="Involved in GAG binding"
FT /evidence="ECO:0000250"
FT DISULFID 33..57
FT /evidence="ECO:0000250|UniProtKB:P10147"
FT DISULFID 34..73
FT /evidence="ECO:0000250|UniProtKB:P10147"
FT CONFLICT 32
FT /note="S -> A (in Ref. 2; AAN76985)"
FT /evidence="ECO:0000305"
FT CONFLICT 38
FT /note="I -> T (in Ref. 2; AAN76985)"
FT /evidence="ECO:0000305"
FT CONFLICT 54
FT /note="N -> S (in Ref. 2; AAN76985)"
FT /evidence="ECO:0000305"
FT CONFLICT 69
FT /note="G -> S (in Ref. 2; AAN76985)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="K -> E (in Ref. 2; AAN76985)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 92 AA; 10120 MW; 021CAA371143D12A CRC64;
MQVSTAALAV LLCTVALCNR ISATFAADTP TSCCFSYISR QIPQNFIADY FETNSQCSKP
GVIFLTKRGR QVCADPSKEW VQKYVSDLEL SA
