ID   CCL4_CANLF              Reviewed;          92 AA.
AC   Q68AZ0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=C-C motif chemokine 4;
DE   AltName: Full=Small-inducible cytokine A4;
DE   Flags: Precursor;
GN   Name=CCL4; Synonyms=SCYA4;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K.,
RA   Tsujimoto H., Iwabuchi S.;
RT   "Expression analysis of chemokine gene in canine atopic dermatitis.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Monokine with inflammatory and chemokinetic properties.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with CCR5 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AB163435; BAD37148.1; -; mRNA.
DR   EMBL; AB183194; BAD83842.1; -; mRNA.
DR   RefSeq; NP_001005250.1; NM_001005250.1.
DR   AlphaFoldDB; Q68AZ0; -.
DR   SMR; Q68AZ0; -.
DR   STRING; 9612.ENSCAFP00000026825; -.
DR   PaxDb; Q68AZ0; -.
DR   Ensembl; ENSCAFT00030038498; ENSCAFP00030033587; ENSCAFG00030020896.
DR   Ensembl; ENSCAFT00040008448; ENSCAFP00040007336; ENSCAFG00040004450.
DR   Ensembl; ENSCAFT00845015652; ENSCAFP00845012169; ENSCAFG00845008857.
DR   GeneID; 448786; -.
DR   KEGG; cfa:448786; -.
DR   CTD; 6351; -.
DR   VEuPathDB; HostDB:ENSCAFG00845008857; -.
DR   eggNOG; ENOG502S8M4; Eukaryota.
DR   GeneTree; ENSGT00940000165089; -.
DR   HOGENOM; CLU_141716_4_0_1; -.
DR   InParanoid; Q68AZ0; -.
DR   OMA; DWVQEYM; -.
DR   OrthoDB; 1575018at2759; -.
DR   TreeFam; TF334888; -.
DR   Reactome; R-CFA-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-CFA-418594; G alpha (i) signalling events.
DR   Proteomes; UP000002254; Chromosome 9.
DR   Bgee; ENSCAFG00000018164; Expressed in cartilage tissue and 45 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..92
FT                   /note="C-C motif chemokine 4"
FT                   /id="PRO_0000326236"
FT   DISULFID        34..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   92 AA;  10197 MW;  7628FBC425BCED9C CRC64;
     MKLCVTVLSL LVLVAAFCSP ALSAPMGSDP PTACCFSYTL RKIPRNFVAD YFETSSLCSQ
     PAVVFQTRRG RQVCANPSEP WVQEYMDDLE LN