CCL4_CHICK
ID CCL4_CHICK Reviewed; 90 AA.
AC Q90826; Q4KS31; Q910C9;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 4.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=C-C motif chemokine 4 homolog;
DE AltName: Full=Macrophage inflammatory protein 1-beta homolog;
DE Short=MIP-1-beta;
DE AltName: Full=Small-inducible cytokine A4 homolog;
DE Flags: Precursor;
GN Name=CCL4; Synonyms=SCYA4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Bone marrow;
RX PubMed=7642115; DOI=10.1016/0378-1119(95)00210-w;
RA Petrenko O., Ischenko I., Enrietto P.J.;
RT "Isolation of a cDNA encoding a novel chicken chemokine homologous to
RT mammalian macrophage inflammatory protein-1 beta.";
RL Gene 160:305-306(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10582310; DOI=10.1046/j.1365-2052.1999.00526-27.x;
RA Hughes S.M., Bumstead N.;
RT "Mapping of the gene encoding a chicken homologue of the mammalian
RT chemokine SCYA4.";
RL Anim. Genet. 30:404-404(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hughes S.M.;
RT "The chicken MIP-like chemokine cluster has a reduced repertoire compared
RT to that of mammals.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Monokine with inflammatory and chemokinetic properties.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; L34553; AAA48747.1; -; mRNA.
DR EMBL; AJ243034; CAB45103.1; -; mRNA.
DR EMBL; AY895166; AAX83390.1; -; Genomic_DNA.
DR RefSeq; NP_001025531.2; NM_001030360.2.
DR AlphaFoldDB; Q90826; -.
DR SMR; Q90826; -.
DR Ensembl; ENSGALT00000093905; ENSGALP00000065186; ENSGALG00000032717.
DR GeneID; 395551; -.
DR KEGG; gga:395551; -.
DR VEuPathDB; HostDB:LOC395551; -.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_4_2_1; -.
DR InParanoid; Q90826; -.
DR OMA; GPDDCCF; -.
DR OrthoDB; 1575018at2759; -.
DR Reactome; R-GGA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-GGA-416476; G alpha (q) signalling events.
DR Reactome; R-GGA-418594; G alpha (i) signalling events.
DR Reactome; R-GGA-444473; Formyl peptide receptors bind formyl peptides and many other ligands.
DR PRO; PR:Q90826; -.
DR Proteomes; UP000000539; Chromosome 19.
DR Bgee; ENSGALG00000032717; Expressed in granulocyte and 10 other tissues.
DR ExpressionAtlas; Q90826; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..90
FT /note="C-C motif chemokine 4 homolog"
FT /id="PRO_0000005169"
FT DISULFID 32..56
FT /evidence="ECO:0000250"
FT DISULFID 33..72
FT /evidence="ECO:0000250"
FT CONFLICT 87
FT /note="L -> M (in Ref. 2; AAA48747 and 3; CAB45103)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 90 AA; 9969 MW; 50AF96781267408F CRC64;
MKVSVAALAV LLIAICYQTS AAPVGSDPPT SCCFTYISRQ LPFSFVADYY ETNSQCPHAG
VVFITRKGRE VCANPENDWV QDYMNKLELN
