1A1L1_MOUSE
ID 1A1L1_MOUSE Reviewed; 502 AA.
AC A2AIG8; Q8CHS6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=1-aminocyclopropane-1-carboxylate synthase-like protein 1;
DE Short=ACC synthase-like protein 1;
GN Name=Accs;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH39569.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH39569.1};
RC TISSUE=Mammary gland {ECO:0000312|EMBL:AAH39569.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Does not catalyze the synthesis of 1-aminocyclopropane-1-
CC carboxylate but is capable of catalyzing the deamination of L-
CC vinylglycine. {ECO:0000250|UniProtKB:Q96QU6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2AIG8-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:15489334};
CC IsoId=A2AIG8-2; Sequence=VSP_052669;
CC -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000255}.
CC -!- CAUTION: Similar to plant 1-aminocyclopropane-1-carboxylate synthases
CC but lacks a number of residues which are necessary for activity.
CC {ECO:0000250|UniProtKB:Q96QU6}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL732472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039569; AAH39569.1; -; mRNA.
DR CCDS; CCDS16457.1; -. [A2AIG8-2]
DR CCDS; CCDS71105.1; -. [A2AIG8-1]
DR RefSeq; NP_001277711.1; NM_001290782.1. [A2AIG8-1]
DR RefSeq; NP_899043.1; NM_183220.3. [A2AIG8-2]
DR RefSeq; XP_006499823.1; XM_006499760.2. [A2AIG8-1]
DR RefSeq; XP_006499824.1; XM_006499761.2. [A2AIG8-1]
DR RefSeq; XP_006499826.1; XM_006499763.2. [A2AIG8-2]
DR RefSeq; XP_006499827.1; XM_006499764.2. [A2AIG8-2]
DR RefSeq; XP_006499828.1; XM_006499765.2. [A2AIG8-2]
DR RefSeq; XP_006499829.1; XM_006499766.2. [A2AIG8-2]
DR AlphaFoldDB; A2AIG8; -.
DR SMR; A2AIG8; -.
DR STRING; 10090.ENSMUSP00000036268; -.
DR iPTMnet; A2AIG8; -.
DR PhosphoSitePlus; A2AIG8; -.
DR EPD; A2AIG8; -.
DR MaxQB; A2AIG8; -.
DR PaxDb; A2AIG8; -.
DR PeptideAtlas; A2AIG8; -.
DR PRIDE; A2AIG8; -.
DR ProteomicsDB; 285528; -. [A2AIG8-1]
DR ProteomicsDB; 285529; -. [A2AIG8-2]
DR Antibodypedia; 13193; 206 antibodies from 26 providers.
DR DNASU; 329470; -.
DR Ensembl; ENSMUST00000041593; ENSMUSP00000036268; ENSMUSG00000040272. [A2AIG8-2]
DR Ensembl; ENSMUST00000068513; ENSMUSP00000065389; ENSMUSG00000040272. [A2AIG8-2]
DR Ensembl; ENSMUST00000111246; ENSMUSP00000106877; ENSMUSG00000040272. [A2AIG8-1]
DR GeneID; 329470; -.
DR KEGG; mmu:329470; -.
DR UCSC; uc008lgj.2; mouse. [A2AIG8-1]
DR CTD; 84680; -.
DR MGI; MGI:1919717; Accs.
DR VEuPathDB; HostDB:ENSMUSG00000040272; -.
DR eggNOG; KOG0256; Eukaryota.
DR GeneTree; ENSGT00940000161101; -.
DR HOGENOM; CLU_017584_1_3_1; -.
DR InParanoid; A2AIG8; -.
DR OMA; HGIEYAT; -.
DR OrthoDB; 1156861at2759; -.
DR PhylomeDB; A2AIG8; -.
DR TreeFam; TF354218; -.
DR BioGRID-ORCS; 329470; 1 hit in 74 CRISPR screens.
DR PRO; PR:A2AIG8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; A2AIG8; protein.
DR Bgee; ENSMUSG00000040272; Expressed in metanephric renal vesicle and 193 other tissues.
DR ExpressionAtlas; A2AIG8; baseline and differential.
DR Genevisible; A2AIG8; MM.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IBA:GO_Central.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006520; P:cellular amino acid metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; SSF53383; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Pyridoxal phosphate; Reference proteome.
FT CHAIN 1..502
FT /note="1-aminocyclopropane-1-carboxylate synthase-like
FT protein 1"
FT /id="PRO_0000318072"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 106
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT MOD_RES 324
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..23
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_052669"
SQ SEQUENCE 502 AA; 56879 MW; 9399891308FC91A0 CRC64;
MFCLPQQEST APTTCTGSAS TQDMDSGYGD GLQGECLRKP DQTQPKLYGV GDPTATFSSD
SSCLSSRGRV IKWFWDSAEE GYRTYHMDEY DEDKNPSGII NLGTSENKLC FDLLSWRLTQ
GDMLHVEPSL LQYPDWRGHL FLREEVAKFL SFYCKSPAPL KPENVVVLNG CASLFSALAT
VLCEAGEALL IPTPYYGAIT QHIYLYGNVR LAYVYLDSKV TGLNTRPFQL TVEKLEMVLQ
GVSSEGVKVK GLILINPQNP LGDVYSPEEL QDFLRFAMRH KLHVIMDEVY MLSVFEESLG
YRSVLSLERL PDPQRTHVMW ATSKDFGMSG LRFGVLYTEN QHVATAVASL CRYHGLSGLV
QHQMAQLLRD HDWISQVYLP ENHARLKAAH TYVSEELRAL GIPFVSRGAG FFIWVDLRKY
LCKGTFEEEA LLWRQFLDNK VLLSSGKTFE CKEPGWFRVV FSDKENRLRL GMQRMRQVLE
GQSQVVEDAS PCHAQEPQSQ PR
