ID   CCL4_MACMU              Reviewed;          92 AA.
AC   Q8HYQ2; Q8HYN3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=C-C motif chemokine 4;
DE   AltName: Full=Macrophage inflammatory protein 1-beta;
DE            Short=MIP-1-beta;
DE   AltName: Full=Small-inducible cytokine A4;
DE   Flags: Precursor;
GN   Name=CCL4; Synonyms=MIP1B, SCYA4;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION.
RX   PubMed=12126650; DOI=10.1006/cyto.2002.0875;
RA   Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.;
RT   "Molecular cloning and sequencing of 25 different rhesus macaque chemokine
RT   cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families
RT   of chemokines.";
RL   Cytokine 18:140-148(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 35-83, INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=12079558; DOI=10.1089/088922202760019329;
RA   Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L.,
RA   Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.;
RT   "Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time
RT   reverse transcriptase-polymerase chain reaction: variations in expression
RT   during chronic primate lentivirus infection.";
RL   AIDS Res. Hum. Retroviruses 18:627-639(2002).
CC   -!- FUNCTION: Monokine with inflammatory and chemokinetic properties.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with CCR5 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Detected in peripheral blood mononuclear cells and
CC       lymph nodes. {ECO:0000269|PubMed:12079558}.
CC   -!- INDUCTION: Up-regulated in SIV or SHIV infected monkeys with decreased
CC       CD4+ T-cell count. {ECO:0000269|PubMed:12079558}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AF449267; AAN76071.1; -; mRNA.
DR   EMBL; AF457196; AAN76986.1; -; mRNA.
DR   RefSeq; NP_001028045.1; NM_001032873.1.
DR   AlphaFoldDB; Q8HYQ2; -.
DR   SMR; Q8HYQ2; -.
DR   STRING; 9544.ENSMMUP00000026461; -.
DR   GeneID; 574217; -.
DR   KEGG; mcc:574217; -.
DR   CTD; 388372; -.
DR   eggNOG; ENOG502S8M4; Eukaryota.
DR   InParanoid; Q8HYQ2; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..92
FT                   /note="C-C motif chemokine 4"
FT                   /id="PRO_0000326237"
FT   DISULFID        34..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..74
FT                   /evidence="ECO:0000250"
FT   CONFLICT        40
FT                   /note="A -> V (in Ref. 1; AAN76986)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   92 AA;  10103 MW;  80B2C2071565F809 CRC64;
     MKLCVTVLSL LVLAAAFCSP ALSAPMGSDP PTSCCFSYTA RKLPRNFVVD YYETSSLCSQ
     PAVVFQTKRG KQVCADPSET WVQEYVNDLE LN