CCL4_PIG
ID CCL4_PIG Reviewed; 92 AA.
AC Q711P4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=C-C motif chemokine 4;
DE AltName: Full=Macrophage inflammatory protein 1-beta;
DE Short=MIP-1-beta;
DE AltName: Full=Small-inducible cytokine A4;
DE Flags: Precursor;
GN Name=CCL4; Synonyms=MIP1B, SCY4A;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Ortuno E., Rodriguez-Carreno M.P., Alonso F., Dominguez J., Ezquerra A.;
RT "Cloning an characterization of the porcine homologous to human chemokine
RT MIP-1beta.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Monokine with inflammatory and chemokinetic properties.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with CCR5 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AJ311717; CAC84398.1; -; mRNA.
DR RefSeq; NP_998944.1; NM_213779.1.
DR AlphaFoldDB; Q711P4; -.
DR SMR; Q711P4; -.
DR STRING; 9823.ENSSSCP00000018754; -.
DR PaxDb; Q711P4; -.
DR Ensembl; ENSSSCT00000065828; ENSSSCP00000044877; ENSSSCG00000032343.
DR Ensembl; ENSSSCT00005009764; ENSSSCP00005005774; ENSSSCG00005006300.
DR Ensembl; ENSSSCT00015086093; ENSSSCP00015035005; ENSSSCG00015064105.
DR Ensembl; ENSSSCT00025028468; ENSSSCP00025012057; ENSSSCG00025020949.
DR Ensembl; ENSSSCT00040105767; ENSSSCP00040048521; ENSSSCG00040076033.
DR Ensembl; ENSSSCT00070012324; ENSSSCP00070010134; ENSSSCG00070006440.
DR GeneID; 396668; -.
DR KEGG; ssc:396668; -.
DR CTD; 6351; -.
DR eggNOG; ENOG502S8M4; Eukaryota.
DR GeneTree; ENSGT00940000165089; -.
DR HOGENOM; CLU_141716_4_0_1; -.
DR InParanoid; Q711P4; -.
DR OMA; DWVQEYM; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Reactome; R-SSC-380108; Chemokine receptors bind chemokines.
DR Reactome; R-SSC-418594; G alpha (i) signalling events.
DR Proteomes; UP000008227; Chromosome 12.
DR Proteomes; UP000314985; Chromosome 12.
DR Bgee; ENSSSCG00000032343; Expressed in right lobe of liver and 31 other tissues.
DR ExpressionAtlas; Q711P4; baseline and differential.
DR Genevisible; Q711P4; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..92
FT /note="C-C motif chemokine 4"
FT /id="PRO_0000326238"
FT DISULFID 34..58
FT /evidence="ECO:0000250"
FT DISULFID 35..74
FT /evidence="ECO:0000250"
SQ SEQUENCE 92 AA; 10207 MW; AB1E0AE5EA9F70E5 CRC64;
MKLCVTVLSL LVLVAAFCSP ALSAPMGSDP PTSCCFTYTV RKLPRNFVTD YYETSSLCSQ
PAVVFQTKKG RQVCANPSDD WVQEYMDDLE LN
