CCL4_RABIT
ID CCL4_RABIT Reviewed; 92 AA.
AC P46632;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=C-C motif chemokine 4;
DE AltName: Full=Immune activation protein 2;
DE Short=ACT-2;
DE AltName: Full=Macrophage inflammatory protein 1-beta;
DE Short=MIP-1-beta;
DE AltName: Full=Small-inducible cytokine A4;
DE Flags: Precursor;
GN Name=CCL4; Synonyms=SCYA4;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=New Zealand white;
RX PubMed=8148323; DOI=10.1093/intimm/6.1.149;
RA Mori S., Goto K., Goto F., Mutakami K., Ohkawara S., Yoshinaga M.;
RT "Dynamic changes in mRNA expression of neutrophils during the course of
RT acute inflammation in rabbits.";
RL Int. Immunol. 6:149-156(1994).
CC -!- FUNCTION: Monokine with inflammatory and chemokinetic properties.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; D17402; BAA04226.1; -; mRNA.
DR PIR; I46730; I46730.
DR RefSeq; NP_001075665.1; NM_001082196.1.
DR AlphaFoldDB; P46632; -.
DR SMR; P46632; -.
DR STRING; 9986.ENSOCUP00000019709; -.
DR GeneID; 100008984; -.
DR KEGG; ocu:100008984; -.
DR CTD; 6351; -.
DR eggNOG; ENOG502S8M4; Eukaryota.
DR InParanoid; P46632; -.
DR OrthoDB; 1575018at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..92
FT /note="C-C motif chemokine 4"
FT /id="PRO_0000005168"
FT DISULFID 34..58
FT /evidence="ECO:0000250"
FT DISULFID 35..74
FT /evidence="ECO:0000250"
SQ SEQUENCE 92 AA; 10066 MW; ECBA8818D42A735C CRC64;
MKLGVTVLSV ALLVAALCPP ALSAPMGSDP PTACCFSYTL RKLPRHFVID YFETTSLCSQ
PAVVFQTKKG RQVCANPSES WVQEYVDDLE LN
