CCL4_RAT
ID CCL4_RAT Reviewed; 92 AA.
AC P50230; A1EC89;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=C-C motif chemokine 4;
DE AltName: Full=Macrophage inflammatory protein 1-beta;
DE Short=MIP-1-beta;
DE AltName: Full=Small-inducible cytokine A4;
DE Flags: Precursor;
GN Name=Ccl4; Synonyms=Mip1b, Scya4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Long Evans; TISSUE=Lung;
RA Jones M.L., Shanley T.P., Schmal H., Friedl H.P., Ward P.A.;
RL Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Dahl salt-sensitive, and Lewis;
RX PubMed=17218081; DOI=10.1016/j.ygeno.2006.12.005;
RA Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P.,
RA Radecki T., Joe B.;
RT "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous
RT variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome
RT 10.";
RL Genomics 89:343-353(2007).
CC -!- FUNCTION: Monokine with inflammatory and chemokinetic properties.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; U06434; AAA96497.1; -; mRNA.
DR EMBL; EF121996; ABL63435.1; -; mRNA.
DR EMBL; EF121997; ABL63436.1; -; mRNA.
DR RefSeq; NP_446310.1; NM_053858.1.
DR AlphaFoldDB; P50230; -.
DR SMR; P50230; -.
DR STRING; 10116.ENSRNOP00000015199; -.
DR PaxDb; P50230; -.
DR GeneID; 116637; -.
DR KEGG; rno:116637; -.
DR CTD; 6351; -.
DR RGD; 620441; Ccl4.
DR eggNOG; ENOG502S8M4; Eukaryota.
DR InParanoid; P50230; -.
DR OrthoDB; 1575018at2759; -.
DR PhylomeDB; P50230; -.
DR Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:P50230; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031726; F:CCR1 chemokine receptor binding; ISO:RGD.
DR GO; GO:0031730; F:CCR5 chemokine receptor binding; ISO:RGD.
DR GO; GO:0008009; F:chemokine activity; IDA:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; ISO:RGD.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IDA:RGD.
DR GO; GO:0030595; P:leukocyte chemotaxis; IDA:RGD.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0043922; P:negative regulation by host of viral transcription; ISO:RGD.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; ISO:RGD.
DR GO; GO:0050850; P:positive regulation of calcium-mediated signaling; ISO:RGD.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISO:RGD.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IMP:RGD.
DR GO; GO:0043117; P:positive regulation of vascular permeability; IDA:RGD.
DR GO; GO:0009636; P:response to toxic substance; ISO:RGD.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..92
FT /note="C-C motif chemokine 4"
FT /id="PRO_0000005167"
FT DISULFID 34..58
FT /evidence="ECO:0000250"
FT DISULFID 35..74
FT /evidence="ECO:0000250"
SQ SEQUENCE 92 AA; 10234 MW; 60B451EEEBC7103D CRC64;
MKLCVSAFSL LLLVAAFCDS VLSAPIGSDP PTSCCFSYTS RKIHRNFVMD YYETSSLCSQ
PAVVFLTKKG RQICADPSEP WVNEYVNDLE LN
