CCL5_BOVIN
ID CCL5_BOVIN Reviewed; 91 AA.
AC O97919; Q3T192;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=C-C motif chemokine 5;
DE AltName: Full=SIS-delta;
DE AltName: Full=Small-inducible cytokine A5;
DE AltName: Full=T-cell-specific protein RANTES;
DE Flags: Precursor;
GN Name=CCL5; Synonyms=SCYA5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Intestine;
RA Aust G., Thamm B., Rost A.K.;
RT "Cloning of Bos taurus RANTES mRNA.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Belted Galloway; TISSUE=Peripheral blood;
RG U.S. Veterinary Immune Reagent Network;
RA Hudgens T., Tompkins D., Baldwin C.L.;
RT "U.S. veterinary immune reagent network: expressed bovine gene sequences.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells
CC and eosinophils. Causes the release of histamine from basophils and
CC activates eosinophils. May activate several chemokine receptors
CC including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G
CC protein-coupled receptor GPR75. Together with GPR75, may play a role in
CC neuron survival through activation of a downstream signaling pathway
CC involving the PI3, Akt and MAP kinases. By activating GPR75 may also
CC play a role in insulin secretion by islet cells.
CC {ECO:0000250|UniProtKB:P13501}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AJ007043; CAA07430.1; -; mRNA.
DR EMBL; EU276060; ABX72058.1; -; mRNA.
DR EMBL; BC102064; AAI02065.1; -; mRNA.
DR RefSeq; NP_787021.1; NM_175827.2.
DR AlphaFoldDB; O97919; -.
DR SMR; O97919; -.
DR STRING; 9913.ENSBTAP00000009463; -.
DR PaxDb; O97919; -.
DR PRIDE; O97919; -.
DR Ensembl; ENSBTAT00000082438; ENSBTAP00000057122; ENSBTAG00000053649.
DR GeneID; 327712; -.
DR KEGG; bta:327712; -.
DR CTD; 6352; -.
DR VEuPathDB; HostDB:ENSBTAG00000053649; -.
DR eggNOG; ENOG502S8D1; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_4_2_1; -.
DR InParanoid; O97919; -.
DR OMA; CCFAYLS; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Reactome; R-BTA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-BTA-418594; G alpha (i) signalling events.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000053649; Expressed in ileocecal valve and 96 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031726; F:CCR1 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:2000110; P:negative regulation of macrophage apoptotic process; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IBA:GO_Central.
DR GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR GO; GO:1901214; P:regulation of neuron death; ISS:UniProtKB.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..91
FT /note="C-C motif chemokine 5"
FT /id="PRO_0000005170"
FT DISULFID 33..57
FT /evidence="ECO:0000250"
FT DISULFID 34..73
FT /evidence="ECO:0000250"
FT CONFLICT 69
FT /note="N -> K (in Ref. 1; CAA07430)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 91 AA; 10059 MW; 930DD38E015B0183 CRC64;
MKVSATAFAV LLMAAALCAP ASASPYASDT TPCCFAYISR PLPRTHVQEY FYTSSKCSMA
AVVFITRKNR QVCANPEKKW VREYINALEL S
