ID   CCL5_CANLF              Reviewed;          91 AA.
AC   Q8HYS0;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=C-C motif chemokine 5;
DE   AltName: Full=Small-inducible cytokine A5;
DE   AltName: Full=T-cell-specific protein RANTES;
DE   Flags: Precursor;
GN   Name=CCL5; Synonyms=SCYA5;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Enomoto A., Kano R., Hasegawa A.;
RT   "Molecular cloning of canine RANTES gene.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells
CC       and eosinophils. Causes the release of histamine from basophils and
CC       activates eosinophils. May activate several chemokine receptors
CC       including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G
CC       protein-coupled receptor GPR75. Together with GPR75, may play a role in
CC       neuron survival through activation of a downstream signaling pathway
CC       involving the PI3, Akt and MAP kinases. By activating GPR75 may also
CC       play a role in insulin secretion by islet cells.
CC       {ECO:0000250|UniProtKB:P13501}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AB098562; BAC53725.1; -; mRNA.
DR   RefSeq; NP_001003010.1; NM_001003010.2.
DR   AlphaFoldDB; Q8HYS0; -.
DR   SMR; Q8HYS0; -.
DR   STRING; 9612.ENSCAFP00000026835; -.
DR   PaxDb; Q8HYS0; -.
DR   GeneID; 403522; -.
DR   KEGG; cfa:403522; -.
DR   CTD; 6352; -.
DR   eggNOG; ENOG502S8D1; Eukaryota.
DR   InParanoid; Q8HYS0; -.
DR   OrthoDB; 1575018at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:1901214; P:regulation of neuron death; ISS:UniProtKB.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..91
FT                   /note="C-C motif chemokine 5"
FT                   /id="PRO_0000005171"
FT   DISULFID        33..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   91 AA;  10179 MW;  01D79538CB8148E7 CRC64;
     MKVSAATFAI LLATATFRAP ASASPYASDT TPCCFAYISG RLPFTHVQEY FYTSSKCSMP
     AVVFVTRKHR QVCANPQKKW VREYINSLEM S