ID   CCL5_CAVPO              Reviewed;          91 AA.
AC   P97272; O09076;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=C-C motif chemokine 5;
DE   AltName: Full=SIS-delta;
DE   AltName: Full=Small-inducible cytokine A5;
DE   AltName: Full=T-cell-specific protein RANTES;
DE   Flags: Precursor;
GN   Name=CCL5; Synonyms=SCYA5;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Dunkin-Hartley;
RA   Campbell E.M., Proudfoot A.E.I., Yoshimura T., Allet B., Wells T.N.C.,
RA   White A.M., Westwick J., Watson M.L.;
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RA   Asano K., Nakamura M., Oguma T., Fukunaga K., Ishizaka A., Yamaguchi K.,
RA   Kanazawa M.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells
CC       and eosinophils. Causes the release of histamine from basophils and
CC       activates eosinophils. May activate several chemokine receptors
CC       including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G
CC       protein-coupled receptor GPR75. Together with GPR75, may play a role in
CC       neuron survival through activation of a downstream signaling pathway
CC       involving the PI3, Akt and MAP kinases. By activating GPR75 may also
CC       play a role in insulin secretion by islet cells.
CC       {ECO:0000250|UniProtKB:P13501}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; U77037; AAC53293.1; -; mRNA.
DR   EMBL; AB002662; BAA19604.1; -; mRNA.
DR   RefSeq; NP_001166398.1; NM_001172927.1.
DR   AlphaFoldDB; P97272; -.
DR   SMR; P97272; -.
DR   STRING; 10141.ENSCPOP00000007949; -.
DR   Ensembl; ENSCPOT00000008932; ENSCPOP00000007949; ENSCPOG00000008852.
DR   GeneID; 100135495; -.
DR   KEGG; cpoc:100135495; -.
DR   CTD; 6352; -.
DR   eggNOG; ENOG502S8D1; Eukaryota.
DR   GeneTree; ENSGT01050000244851; -.
DR   HOGENOM; CLU_141716_4_2_1; -.
DR   InParanoid; P97272; -.
DR   OMA; CCFAYLS; -.
DR   OrthoDB; 1575018at2759; -.
DR   TreeFam; TF334888; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000008852; Expressed in liver and 10 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0031726; F:CCR1 chemokine receptor binding; IEA:Ensembl.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:2000110; P:negative regulation of macrophage apoptotic process; IEA:Ensembl.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:1901214; P:regulation of neuron death; ISS:UniProtKB.
DR   GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..91
FT                   /note="C-C motif chemokine 5"
FT                   /id="PRO_0000005172"
FT   DISULFID        33..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   91 AA;  10088 MW;  7F6A31B751237DB9 CRC64;
     MKVSAAALCV ILTTAALCVP ASASPYASDT TPCCFAYISR ALPRTHIKEY FYTSSKCSNL
     AVVFVTRKNR QVCANPEKKW VREYINSLEM S