ID   CCL5_PIG                Reviewed;          50 AA.
AC   Q29288;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   10-FEB-2021, entry version 88.
DE   RecName: Full=C-C motif chemokine 5;
DE   AltName: Full=SIS-delta;
DE   AltName: Full=Small-inducible cytokine A5;
DE   AltName: Full=T-cell-specific protein RANTES;
DE   Flags: Fragment;
GN   Name=CCL5; Synonyms=SCYA5;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=8672129; DOI=10.1007/s003359900153;
RA   Winteroe A.K., Fredholm M., Davies W.;
RT   "Evaluation and characterization of a porcine small intestine cDNA library:
RT   analysis of 839 clones.";
RL   Mamm. Genome 7:509-517(1996).
CC   -!- FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells
CC       and eosinophils. Causes the release of histamine from basophils and
CC       activates eosinophils. May activate several chemokine receptors
CC       including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G
CC       protein-coupled receptor GPR75. Together with GPR75, may play a role in
CC       neuron survival through activation of a downstream signaling pathway
CC       involving the PI3, Akt and MAP kinases. By activating GPR75 may also
CC       play a role in insulin secretion by islet cells.
CC       {ECO:0000250|UniProtKB:P13501}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; F14636; CAA23170.1; -; mRNA.
DR   STRING; 9823.ENSSSCP00000028561; -.
DR   PaxDb; Q29288; -.
DR   PRIDE; Q29288; -.
DR   eggNOG; ENOG502S8D1; Eukaryota.
DR   InParanoid; Q29288; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:1901214; P:regulation of neuron death; ISS:UniProtKB.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Inflammatory response; Reference proteome; Secreted.
FT   CHAIN           <1..50
FT                   /note="C-C motif chemokine 5"
FT                   /id="PRO_0000144303"
FT   NON_TER         1
SQ   SEQUENCE   50 AA;  5937 MW;  4F2F020125AD1D3E CRC64;
     RCPXHLQEYF YTSSKCSMAA VVFITRKNRQ VCANPEKKWV REYINSLELS