ID   CCL5_SIGHI              Reviewed;          91 AA.
AC   Q91ZL1;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=C-C motif chemokine 5;
DE   AltName: Full=Small-inducible cytokine A5;
DE   AltName: Full=T-cell-specific protein RANTES;
DE   Flags: Precursor;
GN   Name=CCL5; Synonyms=SCYA5;
OS   Sigmodon hispidus (Hispid cotton rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Sigmodontinae; Sigmodon.
OX   NCBI_TaxID=42415;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12085325; DOI=10.1086/340823;
RA   Blanco J.C., Richardson J.Y., Darnell M.E., Rowzee A., Pletneva L.M.,
RA   Porter D.D., Prince G.A.;
RT   "Cytokine and chemokine gene expression after primary and secondary
RT   respiratory syncytial virus infection in cotton rats.";
RL   J. Infect. Dis. 185:1780-1785(2002).
CC   -!- FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells
CC       and eosinophils. Causes the release of histamine from basophils and
CC       activates eosinophils. May activate several chemokine receptors
CC       including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G
CC       protein-coupled receptor GPR75. Together with GPR75, may play a role in
CC       neuron survival through activation of a downstream signaling pathway
CC       involving the PI3, Akt and MAP kinases. By activating GPR75 may also
CC       play a role in insulin secretion by islet cells.
CC       {ECO:0000250|UniProtKB:P13501}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AF421391; AAL16932.1; -; mRNA.
DR   AlphaFoldDB; Q91ZL1; -.
DR   SMR; Q91ZL1; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:1901214; P:regulation of neuron death; ISS:UniProtKB.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..91
FT                   /note="C-C motif chemokine 5"
FT                   /id="PRO_0000005181"
FT   DISULFID        33..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   91 AA;  10082 MW;  D0D6EAEABE4242FF CRC64;
     MKISAAVLTV VLMAASLCAP ASASPNGSDT IPCCFAYLSA VLPRAHVKEY FYTSSKCSNF
     AVVFVTRRNR QVCANPKKKW VQEYINYLEL K