CCL6_RAT
ID CCL6_RAT Reviewed; 115 AA.
AC Q68FP3; A1EC85; Q6IVB4;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=C-C motif chemokine 6;
DE AltName: Full=Small-inducible cytokine A6;
DE Flags: Precursor;
GN Name=Ccl6;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Guo B., Li W., Zhang S.;
RT "Molecular cloning and characterization of a rat chemokine-like cytokine.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Dahl salt-sensitive, and Lewis;
RX PubMed=17218081; DOI=10.1016/j.ygeno.2006.12.005;
RA Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P.,
RA Radecki T., Joe B.;
RT "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous
RT variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome
RT 10.";
RL Genomics 89:343-353(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAT39514.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY620903; AAT39514.1; ALT_INIT; mRNA.
DR EMBL; EF121992; ABL63431.1; -; mRNA.
DR EMBL; EF121993; ABL63432.1; -; mRNA.
DR EMBL; BC079460; AAH79460.1; -; mRNA.
DR RefSeq; NP_001004202.1; NM_001004202.2.
DR AlphaFoldDB; Q68FP3; -.
DR SMR; Q68FP3; -.
DR STRING; 10116.ENSRNOP00000048296; -.
DR PaxDb; Q68FP3; -.
DR GeneID; 287910; -.
DR KEGG; rno:287910; -.
DR CTD; 20305; -.
DR RGD; 1303200; Ccl6.
DR VEuPathDB; HostDB:ENSRNOG00000030021; -.
DR eggNOG; ENOG502TJX7; Eukaryota.
DR HOGENOM; CLU_141716_4_1_1; -.
DR InParanoid; Q68FP3; -.
DR OMA; RFIYYFP; -.
DR OrthoDB; 1575018at2759; -.
DR PhylomeDB; Q68FP3; -.
DR TreeFam; TF334888; -.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-444473; Formyl peptide receptors bind formyl peptides and many other ligands.
DR PRO; PR:Q68FP3; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000030021; Expressed in lung and 18 other tissues.
DR Genevisible; Q68FP3; RN.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; ISO:RGD.
DR GO; GO:0008009; F:chemokine activity; IDA:RGD.
DR GO; GO:0006915; P:apoptotic process; TAS:RGD.
DR GO; GO:0060326; P:cell chemotaxis; IDA:RGD.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..115
FT /note="C-C motif chemokine 6"
FT /id="PRO_0000041846"
FT DISULFID 49..72
FT /evidence="ECO:0000250"
FT DISULFID 50..88
FT /evidence="ECO:0000250"
FT DISULFID 59..99
FT /evidence="ECO:0000250"
FT CONFLICT 16
FT /note="V -> D (in Ref. 1; AAT39514)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 115 AA; 12652 MW; 6CCEB9AC300846FF CRC64;
MRHSKTAISF FILVAVLGSQ AGLIQDTVKE DRPFNPTIIH QGFQDSSDCC FSYASQIPCS
RFIYYFPTSG GCTKPGIIFV TRKRKRVCAN PSDQRVQTCI STLKLGPRSG NSAIA
