CCL7_MOUSE
ID CCL7_MOUSE Reviewed; 97 AA.
AC Q03366;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=C-C motif chemokine 7;
DE AltName: Full=Intercrine/chemokine MARC;
DE AltName: Full=Monocyte chemoattractant protein 3;
DE AltName: Full=Monocyte chemotactic protein 3;
DE Short=MCP-3;
DE AltName: Full=Protein FIC;
DE AltName: Full=Small-inducible cytokine A7;
DE Flags: Precursor;
GN Name=Ccl7; Synonyms=Fic, Mcp3, Scya7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mast cell;
RX PubMed=1281219; DOI=10.1084/jem.176.6.1773;
RA Kulmburg P.A., Huber N.E., Scheer B.J., Wrann M., Baumruker T.;
RT "Immunoglobulin E plus antigen challenge induces a novel
RT intercrine/chemokine in mouse mast cells.";
RL J. Exp. Med. 176:1773-1778(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8002978; DOI=10.1006/bbrc.1994.1729;
RA Thirion S., Nys G., Fiten P., Masure S., van Damme J., Opdenakker G.;
RT "Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and
RT identification as MARC/FIC.";
RL Biochem. Biophys. Res. Commun. 201:493-499(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RA Werner F.;
RL Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8455595; DOI=10.1128/mcb.13.4.2020-2030.1993;
RA Heinrich J.N., Ryseck R.P., Macdonald-Bravo H., Bravo R.;
RT "The product of a novel growth factor-activated gene, fic, is a
RT biologically active 'C-C'-type cytokine.";
RL Mol. Cell. Biol. 13:2020-2030(1993).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7989769;
RA Jarmin D.I., Kulmburg P.A., Huber N.E., Baumann G.,
RA Prieschl-Strassmayr E.E., Baumruker T.;
RT "A transcription factor with AP3-like binding specificity mediates gene
RT regulation after an allergic triggering with IgE and Ag in mouse mast
RT cells.";
RL J. Immunol. 153:5720-5729(1994).
RN [6]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B10.S/J, and SJL/J; TISSUE=Spleen;
RX PubMed=10438970;
RA Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W.,
RA Blankenhorn E.P.;
RT "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte
RT chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for
RT eae7, a locus controlling susceptibility to monophasic
RT remitting/nonrelapsing experimental allergic encephalomyelitis.";
RL J. Immunol. 163:2262-2266(1999).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Chemotactic factor that attracts monocytes and eosinophils,
CC but not neutrophils. Augments monocyte anti-tumor activity (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Interacts with TNFAIP6 (via Link domain).
CC {ECO:0000250|UniProtKB:P80098}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; Z12297; CAA78169.1; -; mRNA.
DR EMBL; L04694; AAA37516.1; -; mRNA.
DR EMBL; S71251; AAB30997.1; -; mRNA.
DR EMBL; X70058; CAA49662.1; -; Genomic_DNA.
DR EMBL; AF128193; AAF22534.1; -; mRNA.
DR EMBL; AF128194; AAF22535.1; -; mRNA.
DR EMBL; AK078827; BAC37413.1; -; mRNA.
DR EMBL; BC061126; AAH61126.1; -; mRNA.
DR CCDS; CCDS36245.1; -.
DR PIR; A48093; A48093.
DR RefSeq; NP_038682.1; NM_013654.3.
DR AlphaFoldDB; Q03366; -.
DR SMR; Q03366; -.
DR BioGRID; 203131; 1.
DR STRING; 10090.ENSMUSP00000021011; -.
DR GlyGen; Q03366; 1 site.
DR PaxDb; Q03366; -.
DR PeptideAtlas; Q03366; -.
DR PRIDE; Q03366; -.
DR Antibodypedia; 15482; 734 antibodies from 35 providers.
DR DNASU; 20306; -.
DR Ensembl; ENSMUST00000021011; ENSMUSP00000021011; ENSMUSG00000035373.
DR GeneID; 20306; -.
DR KEGG; mmu:20306; -.
DR UCSC; uc007kmq.2; mouse.
DR CTD; 6354; -.
DR MGI; MGI:99512; Ccl7.
DR VEuPathDB; HostDB:ENSMUSG00000035373; -.
DR eggNOG; ENOG502S6ZP; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_1_0_1; -.
DR InParanoid; Q03366; -.
DR OMA; TTCCYRF; -.
DR OrthoDB; 1575018at2759; -.
DR PhylomeDB; Q03366; -.
DR TreeFam; TF334888; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR BioGRID-ORCS; 20306; 3 hits in 74 CRISPR screens.
DR PRO; PR:Q03366; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q03366; protein.
DR Bgee; ENSMUSG00000035373; Expressed in stroma of bone marrow and 84 other tissues.
DR ExpressionAtlas; Q03366; baseline and differential.
DR Genevisible; Q03366; MM.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031726; F:CCR1 chemokine receptor binding; ISO:MGI.
DR GO; GO:0031727; F:CCR2 chemokine receptor binding; IPI:BHF-UCL.
DR GO; GO:0008009; F:chemokine activity; ISO:MGI.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0071361; P:cellular response to ethanol; ISO:MGI.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; ISO:MGI.
DR GO; GO:0048245; P:eosinophil chemotaxis; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISO:MGI.
DR GO; GO:0008360; P:regulation of cell shape; ISO:MGI.
DR GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Heparin-binding;
KW Inflammatory response; Pyrrolidone carboxylic acid; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..97
FT /note="C-C motif chemokine 7"
FT /id="PRO_0000005184"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P80098"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 33..57
FT /evidence="ECO:0000250"
FT DISULFID 34..73
FT /evidence="ECO:0000250"
FT CONFLICT 57..63
FT /note="Missing (in Ref. 5; CAA49662)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="A -> R (in Ref. 4; AAA37516)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 97 AA; 10999 MW; B94FDA6DF1EF6140 CRC64;
MRISATLLCL LLIAAAFSIQ VWAQPDGPNA STCCYVKKQK IPKRNLKSYR RITSSRCPWE
AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTPTPKP
