CCL7_RAT
ID CCL7_RAT Reviewed; 97 AA.
AC Q9QXY8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=C-C motif chemokine 7;
DE AltName: Full=Monocyte chemoattractant protein 3;
DE AltName: Full=Monocyte chemotactic protein 3;
DE Short=MCP-3;
DE AltName: Full=Small-inducible cytokine A7;
DE Flags: Precursor;
GN Name=Ccl7; Synonyms=Mcp3, Scya7;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10521584; DOI=10.1016/s0169-328x(99)00203-x;
RA Wang X., Li X., Yaish-Ohad S., Sarau H.M., Barone F.C., Feuerstein G.Z.;
RT "Molecular cloning and expression of the rat monocyte chemotactic protein-3
RT gene: a possible role in stroke.";
RL Brain Res. Mol. Brain Res. 71:304-312(1999).
CC -!- FUNCTION: Chemotactic factor that attracts monocytes and eosinophils,
CC but not neutrophils. Augments monocyte anti-tumor activity (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Interacts with TNFAIP6 (via Link domain).
CC {ECO:0000250|UniProtKB:P80098}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AF154245; AAF24172.1; -; Genomic_DNA.
DR RefSeq; NP_001007613.1; NM_001007612.1.
DR AlphaFoldDB; Q9QXY8; -.
DR SMR; Q9QXY8; -.
DR STRING; 10116.ENSRNOP00000000256; -.
DR GlyGen; Q9QXY8; 1 site.
DR PaxDb; Q9QXY8; -.
DR Ensembl; ENSRNOT00000000256; ENSRNOP00000000256; ENSRNOG00000000239.
DR GeneID; 287561; -.
DR KEGG; rno:287561; -.
DR CTD; 6354; -.
DR RGD; 1359152; Ccl7.
DR eggNOG; ENOG502S6ZP; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_1_0_1; -.
DR InParanoid; Q9QXY8; -.
DR OMA; TTCCYRF; -.
DR OrthoDB; 1575018at2759; -.
DR PhylomeDB; Q9QXY8; -.
DR TreeFam; TF334888; -.
DR Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR PRO; PR:Q9QXY8; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000000239; Expressed in stomach and 17 other tissues.
DR Genevisible; Q9QXY8; RN.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031726; F:CCR1 chemokine receptor binding; ISO:RGD.
DR GO; GO:0031727; F:CCR2 chemokine receptor binding; ISO:RGD.
DR GO; GO:0008009; F:chemokine activity; ISO:RGD.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0071361; P:cellular response to ethanol; IDA:RGD.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; ISO:RGD.
DR GO; GO:0048245; P:eosinophil chemotaxis; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISO:RGD.
DR GO; GO:0008360; P:regulation of cell shape; ISO:RGD.
DR GO; GO:0010332; P:response to gamma radiation; IEP:RGD.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Heparin-binding;
KW Inflammatory response; Pyrrolidone carboxylic acid; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..97
FT /note="C-C motif chemokine 7"
FT /id="PRO_0000005185"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P80098"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 33..57
FT /evidence="ECO:0000250"
FT DISULFID 34..73
FT /evidence="ECO:0000250"
SQ SEQUENCE 97 AA; 10906 MW; AEDBB7BD9288F0C4 CRC64;
MQISAALLCV LLTAAAFTVH VWAQPDGTNS STCCYVKKQK IPKRNLKSYR KITSSRCPWE
AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTSTPKP
