CCL8_BOVIN
ID CCL8_BOVIN Reviewed; 99 AA.
AC Q09141; A5PJH3; Q95MD5;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=C-C motif chemokine 8;
DE AltName: Full=Monocyte chemoattractant protein 2;
DE AltName: Full=Monocyte chemotactic protein 2;
DE Short=MCP-2;
DE AltName: Full=Small-inducible cytokine A8;
DE Flags: Precursor;
GN Name=CCL8; Synonyms=MCP2, SCYA8;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=8286035; DOI=10.1089/dna.1994.13.1;
RA Wempe F., Hanes J., Scheit K.H.;
RT "Cloning of the gene for bovine monocyte chemoattractant protein-2.";
RL DNA Cell Biol. 13:1-8(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Werling D.;
RT "Role of chemokines in respiratory syncytial virus infection.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chemotactic factor that attracts monocytes. This protein can
CC bind heparin.
CC -!- SUBUNIT: Monomer or homodimer; in equilibrium. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK94451.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; S67954; AAD14005.1; -; mRNA.
DR EMBL; S67956; AAB29750.1; -; Genomic_DNA.
DR EMBL; AF399641; AAK94451.1; ALT_INIT; mRNA.
DR EMBL; BC142112; AAI42113.1; -; mRNA.
DR RefSeq; NP_776432.1; NM_174007.1.
DR AlphaFoldDB; Q09141; -.
DR SMR; Q09141; -.
DR STRING; 9913.ENSBTAP00000018757; -.
DR PaxDb; Q09141; -.
DR PRIDE; Q09141; -.
DR Ensembl; ENSBTAT00000018757; ENSBTAP00000018757; ENSBTAG00000014113.
DR GeneID; 281044; -.
DR KEGG; bta:281044; -.
DR CTD; 6355; -.
DR VEuPathDB; HostDB:ENSBTAG00000014113; -.
DR eggNOG; ENOG502S8M4; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_1_0_1; -.
DR InParanoid; Q09141; -.
DR OMA; SIPVTCC; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000014113; Expressed in intramuscular adipose tissue and 94 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0016004; F:phospholipase activator activity; IEA:Ensembl.
DR GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0044828; P:negative regulation by host of viral genome replication; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Heparin-binding;
KW Inflammatory response; Pyrrolidone carboxylic acid; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250|UniProtKB:P80075"
FT CHAIN 24..99
FT /note="C-C motif chemokine 8"
FT /id="PRO_0000005186"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P80075"
FT DISULFID 34..59
FT /evidence="ECO:0000250"
FT DISULFID 35..75
FT /evidence="ECO:0000250"
SQ SEQUENCE 99 AA; 10900 MW; 01974CDB3FF9119B CRC64;
MKVSAGILCL LLVAATFGTQ VLAQPDSVST PITCCFSVIN GKIPFKKLDS YTRITNSQCP
QEAVIFKTKA DRDVCADPKQ KWVQTSIRLL DQKSRTPKP
